2-[methoxy(phenyl)methyl]phenylmethanol | 125593-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[methoxy(phenyl)methyl]phenylmethanol
• 英文别名: [2-[Methoxy(phenyl)methyl]phenyl]methanol
• CAS: 125593-29-5
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: OJZXVZPZBOWYBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[methoxy(phenyl)methyl]phenylmethanol 在 吡啶 、 氯化亚砜 、 sodium azide 、 三苯基膦 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 25.17h， 生成 1-(isothiocyanatomethyl)-2-[methoxy(phenyl)methyl]benzene
  参考文献：
  名称：

  Synthesis of N,N-Disubstituted 1-Aryl-1,3-dihydro-2H-isoindole-2-carbothioamides

  摘要：

  A convenient method for the synthesis of N,N-disubstituted 1-aryl-1,3-dihydro-2H-isoindole-2-carbothioamides starting from 2-[aryl(methoxy)methyl]phenyl bromides is described. Thus, the reaction of 1-[aryl(methoxy)methyl]-2-(isothiocyanatomethyl)benzenes, derived from the starting materials by an easily operated five-step sequence under mild conditions, with secondary amines provides the corresponding thiourea derivatives, which cyclize on treatment with methanesulfonic acid to afford the desired products.

  DOI：

  10.3987/com-16-13421
• 作为产物：
  描述：

  2-(methoxy(phenyl)methyl)benzaldehyde 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 0.25h， 以0.51 g的产率得到2-[methoxy(phenyl)methyl]phenylmethanol
  参考文献：
  名称：

  Synthesis of N,N-Disubstituted 1-Aryl-1,3-dihydro-2H-isoindole-2-carbothioamides

  摘要：

  A convenient method for the synthesis of N,N-disubstituted 1-aryl-1,3-dihydro-2H-isoindole-2-carbothioamides starting from 2-[aryl(methoxy)methyl]phenyl bromides is described. Thus, the reaction of 1-[aryl(methoxy)methyl]-2-(isothiocyanatomethyl)benzenes, derived from the starting materials by an easily operated five-step sequence under mild conditions, with secondary amines provides the corresponding thiourea derivatives, which cyclize on treatment with methanesulfonic acid to afford the desired products.

  DOI：

  10.3987/com-16-13421

文献信息

• Carbenes and the oxygen-hydrogen bond: hydroxyalkyl-substituted arylcarbenes
  作者：Wolfgang Kirmse、Klaus Kund

  DOI：10.1021/jo00295a018

  日期：1990.4
• Synthesis of 1-Aryl-1,3-dihydrobenzo[c]thiophenes by Acid-Mediated Cyclization of 1-[Aryl(methoxy)methyl]-2-[(tert-butylsulfanyl)methyl]benzenes
  作者：Kazuhiro Kobayashi、Yuuho Shigemura

  DOI：10.3987/com-16-13579

  日期：——

  A convenient method for the preparation of 1-aryl-1,3-dihydrobenzo[c]thiophenes has been developed using a three-step sequence starting from 2-[aryl(methoxy)methyl]benzyl alcohols. Thus, treatment of the starting materials with thionyl chloride gives the corresponding benzyl chlorides, which are allowed to react with sodium tert-butyl mercaptide to yield 1-aryl(methoxy)methyl]-2-[(tert-butylsulfanyl)methyl]benzenes. Finally, these compounds undergo cyclization on treatment with concentrated hydrobromic acid to provide the desired products in reasonable yields.
• KIRMSE, WOLFGANG;KUND, KLAUS, J. ORG. CHEM., 55,(1990) N, C. 2325-2332
  作者：KIRMSE, WOLFGANG、KUND, KLAUS

  DOI：——

  日期：——