4-(4-ethynylphenylcarbamoyl)butyric acid | 817638-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-ethynylphenylcarbamoyl)butyric acid
• 英文别名: 5-(4-ethynylphenylamino)-5-oxopentanoic acid；4-(4-Ethynyl-phenylcarbamoyl)-butyric acid；5-(4-ethynylanilino)-5-oxopentanoic acid
• CAS: 817638-76-9
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.251
• InChiKey: WJCUQNFBLCEYHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-azidocoumarin 、 4-(4-ethynylphenylcarbamoyl)butyric acid 在 copper(II) sulfate sodium ascorbate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  3-azidocoumarins和乙炔的发荧光的1,3-偶极环加成反应。

  摘要：

  铜（I）催化的非荧光3-azidocoumarins和末端炔烃的1,3-偶极环加成反应可提供强烈的荧光1,2,3-三唑产物。此反应的温和条件使我们能够构建一个大型的纯荧光香豆素染料库。由于叠氮化物和炔烃对生物系统都非常惰性，因此该反应在生物共轭和生物成像应用中具有潜力。[反应：看文字]

  DOI：

  10.1021/ol047955x
• 作为产物：
  描述：

  戊二酸酐 、 4-乙炔基苯胺 以 二氯甲烷 为溶剂， 反应 6.0h， 以96%的产率得到4-(4-ethynylphenylcarbamoyl)butyric acid
  参考文献：
  名称：

  3-azidocoumarins和乙炔的发荧光的1,3-偶极环加成反应。

  摘要：

  铜（I）催化的非荧光3-azidocoumarins和末端炔烃的1,3-偶极环加成反应可提供强烈的荧光1,2,3-三唑产物。此反应的温和条件使我们能够构建一个大型的纯荧光香豆素染料库。由于叠氮化物和炔烃对生物系统都非常惰性，因此该反应在生物共轭和生物成像应用中具有潜力。[反应：看文字]

  DOI：

  10.1021/ol047955x

文献信息

• MATERIAL FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, PATTERNING PROCESS, AND COMPOUND
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20210286266A1

  公开（公告）日：2021-09-16

  The present invention is a material for forming an organic film, including: a compound shown by the following general formula (1); and an organic solvent, where in the general formula (1), X represents an organic group with a valency of “n” having 2 to 50 carbon atoms or an oxygen atom, “n” represents an integer of 1 to 10 , and R 1 independently represents any of the following general formulae (2), where in the general formulae (2), broken lines represent attachment points to X, and Q 1 represents a monovalent organic group containing a carbonyl group, at least a part of which is a group shown by the following general formulae (3), where in the general formulae (3), broken lines represent attachment points, X 1 represents a single bond or a divalent organic group having 1 to 20 carbon atoms optionally having a substituent when the organic group has an aromatic ring, R 2 represents a hydrogen atom, a methyl group, an ethyl group, or a phenyl group, and ** represents an attachment point. An object of the present invention is to provide a material for forming an organic film for forming an organic film having dry etching resistance, and also having high filling and planarizing properties and adhesion to a substrate.

  本发明是一种用于形成有机薄膜的材料，包括：由以下通用式（1）所示的化合物；和有机溶剂，在通用式（1）中，X代表具有2至50个碳原子或一个氧原子的价为“n”的有机基团，“n”表示1到10的整数，R1独立地表示以下通用式（2）中的任何一种，其中在通用式（2）中，虚线表示连接点到X，Q1表示含有羰基的一价有机基团，其中至少部分是以下通用式（3）所示的基团，其中在通用式（3）中，虚线表示连接点，X1表示单键或具有1到20个碳原子的二价有机基团，在有机基团具有芳香环时可选地具有取代基，R2表示氢原子、甲基基团、乙基基团或苯基团，**表示连接点。本发明的目的是提供一种用于形成具有干法刻蚀抗性的有机薄膜的材料，同时具有高填充和平整化性能以及对基底的粘附性。
• Chemoselective Fluorgenic Molecular Linkers and Methods for Their Preparation and Use
  申请人：Wang Qian

  公开号：US20070224695A1

  公开（公告）日：2007-09-27

  The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide substituent group with another linker having a cyano or an alkyne substituent group. A kit is also provided.

  本发明描述了一种生物共轭策略和在其中有用的化合物，当两个分子或超分子实体通过一个含有偶氮基或卤素取代基的连接剂与另一个含有氰基或炔基取代基的连接剂进行化学选择性组合时，会产生荧光信号。同时还提供了一种试剂盒。
• Compositions, probes, and conjugates and uses thereof
  申请人：Third Wave Technologies, Inc.

  公开号：US07674924B2

  公开（公告）日：2010-03-09

  The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and said first and second molecules are mixed under conditions to form a conjugate with a 1,2,3-triazol group. In further embodiments, a nucleotide is functionalized with an alkynyl group, a dye is functionalized with an azide group, and mixing the nucleotide and the dye forms a conjugate capable of emitting light.

  本发明涉及用作探针和其他应用的组合物，以及它们的使用方法。在某些实施例中，核苷酸经过处理并与染料功能化。在某些实施例中，第一分子与炔基团功能化，第二分子与偶氮基团功能化，然后在条件下混合第一和第二分子以形成带有1,2,3-三唑基团的共轭物。在进一步的实施例中，核苷酸经过处理并与炔基团功能化，染料与偶氮基团功能化，混合核苷酸和染料形成能够发光的共轭物。
• Towards click bioconjugations on cube-octameric silsesquioxane scaffolds
  作者：Sebastian Fabritz、Dirk Heyl、Viktor Bagutski、Martin Empting、Eckhard Rikowski、Holm Frauendorf、Ildiko Balog、Wolf-Dieter Fessner、Jörg. J. Schneider、Olga Avrutina、Harald Kolmar

  DOI：10.1039/b923393h

  日期：——

  Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including the first effective conjugation with a fully unprotected functional peptide towards a POSS assembled peptide octamer.

  报告了基于立方八聚体硅倍半氧烷（POSS）的铜催化叠氮-炔烃 [3+2] 环加成共轭支架。报告描述了八叠氮基和八炔基官能化 POSS 模板的合成路线，无需笼式重排。研究人员进行了一系列单击耦合，包括首次与完全未受保护的功能肽进行有效共轭，以获得 POSS 组装的肽八聚体。
• Chemoselective fluorgenic molecular linkers and methods for their preparation and use
  申请人：University of South Carolina

  公开号：US07745229B2

  公开（公告）日：2010-06-29

  The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide substituent group with another linker having a cyano or an alkyne substituent group. A kit is also provided.

  本发明描述了一种生物共轭策略和化合物，其在其中有用，其中当通过一种具有偶氮或卤素取代基的连接剂与另一种具有氰或炔基取代基的连接剂进行化学选择性结合时，产生荧光信号，两种分子或超分子实体链接。同时还提供了一种工具包。