(R)-1-(p-methylbenzoyl)-3-(p-methylbenzoylamino)piperidine | 1050447-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-1-(p-methylbenzoyl)-3-(p-methylbenzoylamino)piperidine
• 英文别名: 4-methyl-N-[(3R)-1-(4-methylbenzoyl)piperidin-3-yl]benzamide
• CAS: 1050447-02-3
• 化学式: C₂₁H₂₄N₂O₂
• 分子量: 336.434
• InChiKey: OQGQIXOILFJMCJ-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-1-(对甲基苯甲酰基)-3-氨基哌啶 、 对甲基苯甲酰氯 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 3.0h， 以59%的产率得到(R)-1-(p-methylbenzoyl)-3-(p-methylbenzoylamino)piperidine
  参考文献：
  名称：

  METHOD FOR PRODUCING OPTICALLY ACTIVE 3-AMINOPIPERIDINE OR SALT THEREOF

  摘要：

  本发明涉及一种生产光学活性3-氨基哌啶或其盐的方法。在该方法中，通过在有机体衍生的酶源存在下，立体选择性水解一个混合的尼皮科酰胺来获得光学活性尼皮科酰胺和光学活性尼皮科酸，然后通过酰化、霍夫曼重排、氨基保护基的去除和进一步的去保护，将光学活性尼皮科酰胺转化为光学活性氨基哌啶或其盐；或者通过用BOC进行选择性保护、霍夫曼重排和进一步的去保护，将光学活性尼皮科酰胺转化为光学活性氨基哌啶或其盐。通过本发明，可以从廉价且易得的起始材料中通过简单的工业制造方法生产出一种作为药物中间体有用的光学活性3-氨基哌啶或其盐。

  公开号：

  US20100105917A1

文献信息

• Method for producing optically active 3-aminopiperidine or salt thereof
  申请人：Kaneka Corporation

  公开号：US08338142B2

  公开（公告）日：2012-12-25

  The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.

  本发明涉及一种制备光学活性3-氨基哌啶或其盐的方法。在该方法中，利用来源于生物体的酶源，在立体选择性水解中得到光学活性的尼佩考胺和光学活性的尼佩考酸，然后通过酰化、霍夫曼重排、氨基保护基的去除和进一步去保护，或者通过选择性BOC保护、霍夫曼重排和进一步去保护将光学活性的尼佩考胺转化为光学活性的氨基哌啶或其盐。本发明可以通过简单的工业制造方法，从廉价易得的起始材料中制备出用于制药中间体的光学活性3-氨基哌啶或其盐。
• ARYL-PIPERIDINE DERIVATIVES
  申请人：Artax Biopharma Inc.

  公开号：US20200131125A1

  公开（公告）日：2020-04-30

  An aryl-piperidine derivative of formula I, wherein the meaning of R 3 , X, Cz, and Cy is that specified in the description, for use as inhibitors of T cells.
• US8338142B2
  申请人：——

  公开号：US8338142B2

  公开（公告）日：2012-12-25
• METHOD FOR PRODUCING OPTICALLY ACTIVE 3-AMINOPIPERIDINE OR SALT THEREOF
  申请人：Mori Kohei

  公开号：US20100105917A1

  公开（公告）日：2010-04-29

  The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.

  本发明涉及一种生产光学活性3-氨基哌啶或其盐的方法。在该方法中，通过在有机体衍生的酶源存在下，立体选择性水解一个混合的尼皮科酰胺来获得光学活性尼皮科酰胺和光学活性尼皮科酸，然后通过酰化、霍夫曼重排、氨基保护基的去除和进一步的去保护，将光学活性尼皮科酰胺转化为光学活性氨基哌啶或其盐；或者通过用BOC进行选择性保护、霍夫曼重排和进一步的去保护，将光学活性尼皮科酰胺转化为光学活性氨基哌啶或其盐。通过本发明，可以从廉价且易得的起始材料中通过简单的工业制造方法生产出一种作为药物中间体有用的光学活性3-氨基哌啶或其盐。