2-hydrazino-5-phenylpyrimidine | 75175-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-hydrazino-5-phenylpyrimidine
• 英文别名: 5-phenyl-2-hydrazinopyrimidine；(5-phenylpyrimidin-2-yl)hydrazine
• CAS: 75175-43-8
• 化学式: C₁₀H₁₀N₄
• mdl: MFCD19201524
• 分子量: 186.216
• InChiKey: LMFJCTVBDCMPAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydrazino-5-phenylpyrimidine 在 sodium hydride 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.17h， 生成 2-(p-heptyloxyphenylazo)-5-phenylpyrimidine
  参考文献：
  名称：

  Arylazopyrimidines as dichroic dyes for liquid crystals

  摘要：

  DOI：

  10.1007/bf00531662
• 作为产物：
  描述：

  2-氯-5-苯基嘧啶 在 一水合肼 作用下， 以 吡啶 、 水 为溶剂， 生成 2-hydrazino-5-phenylpyrimidine
  参考文献：
  名称：

  (Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and

  摘要：

  这份披露描述了具有抗焦虑活性的取代的1,2,4-三氮唑[1,5-a]嘧啶和取代的1,2,4-三氮唑[4,3-a]嘧啶。

  公开号：

  US04209621A1

文献信息

• (Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and
  申请人：American Cyanamid Company

  公开号：US04209621A1

  公开（公告）日：1980-06-24

  This disclosure describes substituted 1,2,4-triazolo[1,5-a]pyrimidines and substituted 1,2,4-triazolo[4,3-a]pyrimidines which possess anxiolytic activity.

  这份披露描述了具有抗焦虑活性的取代的1,2,4-三氮唑[1,5-a]嘧啶和取代的1,2,4-三氮唑[4,3-a]嘧啶。
• Methods of Inhibiting Bacterial Virulence and Compounds Relating Thereto
  申请人：Sperandio Vanessa

  公开号：US20100048573A1

  公开（公告）日：2010-02-25

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.

  本发明涉及化合物和方法，用于治疗细菌感染。由于它们的作用机制不涉及杀死细菌或抑制它们的生长，这些化合物诱导细菌耐药性的潜力被最小化。通过抑制细菌的毒力，本发明提供了治疗细菌感染的新方法。
• 3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation
  作者：Fortuna Haviv、James D. Ratajczyk、Robert W. DeNet、Francis A. Kerdesky、Roland L. Walters、Steven P. Schmidt、James H. Holms、Patrick R. Young、George W. Carter

  DOI：10.1021/jm00117a010

  日期：1988.9

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.
• HAVIV, FORTUNA;RATAJCZYK, JAMES D.;DENET, ROBERT W.;KERDESKY, FRANCIS A.;+, J. MED. CHEM., 31,(1988) N 9, C. 1719-1728
  作者：HAVIV, FORTUNA、RATAJCZYK, JAMES D.、DENET, ROBERT W.、KERDESKY, FRANCIS A.、+

  DOI：——

  日期：——
• INHIBITORS TO TARGET HIV-1 NEF-CD80/CD86 INTERACTIONS FOR THERAPEUTIC INTERVENTION
  申请人：NATIONAL CENTRE FOR BIOLOGICAL SCIENCES-TIFR

  公开号：US20220062281A1

  公开（公告）日：2022-03-03

  The compounds of Formula I, II, and III along with their stereoisomers, pharmaceutically acceptable salts, polymorphs, solvates and hydrates thereof are described in the present disclosure. The said compounds restore immune activation in case of infections or a disease associated with an HIV infection in a subject in need thereof.