Rhodium-Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α-Branched Products
作者:Louis K. M. Chan、Darren L. Poole、Di Shen、Mark P. Healy、Timothy J. Donohoe
DOI:10.1002/anie.201307950
日期:2014.1.13
The rhodium‐catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen‐borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α‐branched products with ease. Doubly alkylated ketones can be prepared from methyl ketones and two different alcohols by using a
Palladium nanoparticles immobilized on an amino‐functionalized syndiotactic polystyrene (sPS‐N) served as a novel recyclable catalyst for the dimethylation and cross methyl alkylation of a wide range of ketones with methanol as the methylation agent. This heterogeneous catalyst (Pd@sPS‐N) was highly robust and showed excellent thermal stability and chemical resistance. It not only showed remarkably high
固定在氨基官能化间同立构聚苯乙烯(s PS-N)上的钯纳米粒子是新型可循环利用的催化剂,用于以甲醇为甲基化剂的多种酮的二甲基化和交叉甲基烷基化。这种非均相催化剂(Pd @ s PS-N)非常坚固,并显示出出色的热稳定性和耐化学性。它不仅显示出非常高的活性,而且还可以通过过滤容易地回收而又不损失活性。
Selective reductive α-methylation of chalcone derivatives using methanol
An electron rich, new co-operative iridium(III) complex catalysed tandem conversion of α,β-unsaturated ketones to the α-methylated ketones is described using methanol. Employing this chemoselective protocol, reductive methylation of a wide range of chalcone derivatives, variety of aryl and aliphatic fragment containing α,β-unsaturated ketones along with few biologically important molecules were effectively
Well-Defined Bis(NHC)Mn(I) Complex Catalyzed Tandem Transformation of α,β-Unsaturated Ketones to α-Methylated Ketones Using Methanol
作者:Kasturi Ganguli、Adarsha Mandal、Sabuj Kundu
DOI:10.1021/acscatal.2c04131
日期:2022.10.7
Tandem transformation of α,β-unsaturated ketones to α-methylated ketones by utilizing methanol as both the hydrogen and C1 sources is reported in the presence of a phosphine-free bis-N-heterocyclic carbene-Mn(I) (bis-NHC-Mn(I)) catalyst. The dehydrogenative coupling between methanol and α,β-unsaturated ketones produces the corresponding α-methylated ketones along with 1 equiv of formaldehyde and water