[(2R,3R,4S,5R,6S)-6-[5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridin-2-yl]sulfanyl-3,4,5-triacetyloxyoxan-2-yl]methyl acetate | 488759-84-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2R,3R,4S,5R,6S)-6-[5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridin-2-yl]sulfanyl-3,4,5-triacetyloxyoxan-2-yl]methyl acetate
• CAS: 488759-84-8
• 化学式: C₃₀H₃₂N₂O₁₁S
• 分子量: 628.657
• InChiKey: YCZDHEAPUOFTFS-RHBSMATHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  44.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  177.41
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  [(2R,3R,4S,5R,6S)-6-[5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridin-2-yl]sulfanyl-3,4,5-triacetyloxyoxan-2-yl]methyl acetate 在 氨 作用下， 以 甲醇 为溶剂， 以82%的产率得到5-acetyl-4-(4-methoxyphenyl)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylpyridine-3-carbonitrile
  参考文献：
  名称：

  FIRST GLYCOSIDE SYNTHESIS VIA PIPERIDINIUM SALTS OF HETEROCYCLIC NITROGEN BASES: THE SYNTHESIS OF A NEW CLASS OF DIHYDROPYRIDINE THIOGLYCOSIDES

  摘要：

  A first reported method for preparation of a new class of thioglycosides via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-alpha-D-gluco- and galactopyranosyl bromides has been studied. Comparison with the products obtained from silylated thiopyridines is made.

  DOI：

  10.1081/car-120013502
• 作为产物：
  描述：

  5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridine-2(1H)-thione 在 硫酸氢铵 、 四氯化锡 作用下， 以 乙腈 为溶剂， 反应 54.0h， 生成 [(2R,3R,4S,5R,6S)-6-[5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridin-2-yl]sulfanyl-3,4,5-triacetyloxyoxan-2-yl]methyl acetate
  参考文献：
  名称：

  FIRST GLYCOSIDE SYNTHESIS VIA PIPERIDINIUM SALTS OF HETEROCYCLIC NITROGEN BASES: THE SYNTHESIS OF A NEW CLASS OF DIHYDROPYRIDINE THIOGLYCOSIDES

  摘要：

  A first reported method for preparation of a new class of thioglycosides via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-alpha-D-gluco- and galactopyranosyl bromides has been studied. Comparison with the products obtained from silylated thiopyridines is made.

  DOI：

  10.1081/car-120013502