Cyclopentyloxiran | 88301-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: Cyclopentyloxiran
• 英文别名: cyclopentyl-oxirane；cyclopentylethylene oxide；2-Cyclopentyloxirane
• CAS: 88301-26-2
• 化学式: C₇H₁₂O
• mdl: MFCD17218291
• 分子量: 112.172
• InChiKey: JFFFDMRLXIJHEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 Cyclopentyloxiran
  参考文献：
  名称：

  v. Braun; Muench, Chemische Berichte, 1926, vol. 59, p. 1946

  摘要：

  DOI：

文献信息

• Electronic Structure and Multicatalytic Features of Redox-Active Bis(arylimino)acenaphthene (BIAN)-Derived Ruthenium Complexes
  作者：Arijit Singha Hazari、Ritwika Ray、Md Asmaul Hoque、Goutam Kumar Lahiri

  DOI：10.1021/acs.inorgchem.6b01280

  日期：2016.8.15

  The article examines the newly designed and structurally characterized redox-active BIAN-derived [Ru(trpy)(R-BIAN)Cl]ClO4 ([1a]ClO4–[1c]ClO4), [Ru(trpy)(R-BIAN)(H2O)](ClO4)2 ([3a](ClO4)2–[3c](ClO4)2), and BIAO-derived [Ru(trpy)(BIAO)Cl]ClO4 ([2a]ClO4) (trpy = 2,2′:6′,2′′-terpyridine, R-BIAN = bis(arylimino)acenaphthene (R = H (1a+, 3a2+), 4-OMe (1b+, 3b2+), 4-NO2 (1c+, 3c2+), BIAO = [N-(phenyl)imino]acenapthenone)

  本文研究了新设计和结构表征的氧化还原活性的BIAN衍生的[Ru（trpy）（R-BIAN）Cl] ClO 4（[ 1a ] ClO 4 – [ 1c ] ClO 4），[Ru（trpy）（R -BIAN）（H 2 O）]（ClO 4）2（[ 3a ]（ClO 4）2 – [ 3c ]（ClO 4）2）和BIAO衍生的[Ru（trpy）（BIAO）Cl] ClO 4（[ 2a ] ClO 4）（trpy = 2,2'：6'，2'-terpyridine，R-BIAN =双（芳基）ac啶（R = H（1a +，3a 2+），4-OMe（1b +，3b 2 +），4-NO 2（1c +，3c 2 +），BIAO = [ N-（苯基）亚氨基] ac庚烯）。1 a n – 1c n或2a n的实验（X射线，1 H NMR，光谱电化学，EPR）和DFT / TD-DFT计算共同建立了Ru II –BIAN
• Process for producing 1,3-dialkyl-2-imidazolidinone compound
  申请人：——

  公开号：US20030009035A1

  公开（公告）日：2003-01-09

  There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50 ° C. or higher to give 1,3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A), a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1,3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide. The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.

  提供了一种制备1,3-二烷基-2-咪唑烷酮的方法，该方法使用乙烯氧化物作为第一组分，至少使用以下之一：（A）二氧化碳和一种单烷基胺；（B）单烷基胺的二氧化碳化合物；和（C）1,3-二烷基脲，通过加热至50°C或更高温度来使第一和第二组分反应，得到1,3-二烷基-2-咪唑烷酮，其特点是：单烷基胺的摩尔进料量包括在组分（A）中的单烷基胺的摩尔进料量，单烷基胺的二氧化碳化合物中的单烷基胺部分的摩尔进料量，组分（B），以及1,3-二烷基脲的摩尔进料量的两倍，组分（C），至少是乙烯氧化物的摩尔进料量的三倍。这种发明的制备过程使用工业上易得的乙烯氧化物作为起始物质，并且可以在工业规模上以更高的产率进行适当的操作。
• [EN] THE TOTAL SYNTHESIS OF GLUCOSEPANE AND COMPOUNDS OBTAINED THEREFROM<br/>[FR] SYNTHÈSE TOTALE DE GLUCOSÉPANE ET COMPOSÉS OBTENUS À PARTIR DE CELLE-CI
  申请人：UNIV YALE

  公开号：WO2017053776A1

  公开（公告）日：2017-03-30

  Glucosepane is a structurally complex protein post-translational modification (PTM) believed to exist in all living organisms. Research in humans suggests that glucosepane plays a critical role in the pathophysiology of both diabetes and human aging; yet comprehensive biological investigations of this 'metabolite have been 'greatly hindered by a scarcity of chemically homogeneous material available for study. Glucosepane possesses a unique chemical structure that incorporates a surprising, never-before-prepared non-aromatic tautomer of imidazole (hereafter termed an "iso-imidazole"), rendering it a challenging target for chemical synthesis. In this application, the inventors report the first total synthesis of glucosepane, enabled by the development of a novel one-pot method for preparation of the iso-imidazole core. The synthesis of the present invention is concise (8-steps starting from commercial materials), convergent, high-yielding (12% overall), and enantioselective. These results should prove useful to the art and practice of heterocyclic chemistry, and critical for the study of glucosepane and its role in human health and disease, especially the treatment of diabetic disorders or its impact on aging processes. Methods of synthesis, compounds obtained therefrom, pharmaceutical compositions and methods of treatment provide embodiments of the present invention.

  葡萄糖胺是一种结构复杂的蛋白后翻译修饰（PTM），被认为存在于所有生物体中。人类的研究表明，葡萄糖胺在糖尿病和人类衰老的病理生理学中起着关键作用；然而，对这种“代谢产物”的全面生物学研究受到可供研究的化学均一材料的稀缺性的极大阻碍。葡萄糖胺具有独特的化学结构，其中包含一个令人惊讶的、从未制备过的非芳香咪唑互变异构体（以下简称“异咪唑”），使其成为化学合成的一个具有挑战性的目标。在本申请中，发明人报告了葡萄糖胺的首次全合成，该合成是通过开发一种新型一锅法制备异咪唑核心而实现的。本发明的合成方法简明（从商业材料开始的8步），收率高（总体为12%），对映选择性高。这些结果应该对杂环化学的艺术和实践有用，并且对研究葡萄糖胺及其在人类健康和疾病中的作用、特别是治疗糖尿病或其对衰老过程的影响至关重要。本发明提供了合成方法、从中获得的化合物、制药组合物和治疗方法的实施例。
• Processes for production of optically active epoxides
  申请人：DAICEL CHEMICAL INDUSTRIES CO., LTD.

  公开号：EP0611826A2

  公开（公告）日：1994-08-24

  A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of an epoxide such as 3-chlorostyrene oxide and the product optically active epoxide is recovered. The microorganism able to produce an optically active (S)-epoxide from the mixture of enantiomers of the epoxide include, for example, a microorganism strain belonging to the genus Candida, the genus Rhodosporidium, the genus Rhodococcus and the genus Nosardioides. Examples of the microorganism capable of producing an optically active (R)-epoxide from said mixture include a microorganism strain belonging to the genus Trichosporon, the genus Geotrichum, the genus Corynebacterium, the genus Micrococcus and the genus Brevibacterium. The objective optically active epoxide can efficiently be obtained with ease and simplicity from the corresponding mixture of enantiomers of the epoxide.

  允许微生物或其制剂作用于环氧化物（如 3-氯苯乙烯氧化物）的对映体混合物，并回收光学活性环氧化物产品。能够从环氧化物的对映体混合物中产生光学活性（S）-环氧化物的微生物包括，例如，属于白色念珠菌属、Rhodosporidium 属、Rhodococcus 属和 Nosardioides 属的微生物菌株。能够从所述混合物中产生光学活性（R）-环氧化物的微生物菌株的例子包括属于三孢菌属、革囊菌属、高丽杆菌属、微球菌属和布雷维杆菌属的微生物菌株。从相应的环氧化物对映体混合物中可以高效、简便地获得具有光学活性的环氧化物。
• PROCESS FOR PRODUCING 1,3-DIALKYL-2-IMIDAZOLIDINONE COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1279667A1

  公开（公告）日：2003-01-29

  There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50 °C or higher to give 1, 3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A) , a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1, 3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide. The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.

  本发明提供了一种制备 1，3-二烷基-2-咪唑烷酮的工艺，该工艺以环氧亚 烷为第一组分，使用 (A) 二氧化碳和单烷基胺；(B) 单烷基胺的二氧化碳化合物；和 (C) 1，3-二烷基脲中的至少一种；和 (C) 1，3-二烷基脲，通过在 50℃或更高温度下加热使第一和第二组分反应，得到 1，3-二烷基-2-咪唑烷酮，其特征在于，组分 (A) 中包含的单烷基胺的摩尔进料总量 、单烷基胺二氧化碳化合物的单烷基胺部分的摩尔进料量，组分(B)，以及 1，3-二烷基脲的摩尔进料量的双倍，组分(C)，至少是环氧亚烷基摩尔进料量的三倍。 本发明的制备工艺使用工业上容易获得的环氧亚烷烃作为起始原料，可以适当地在工业规模上以更高的产率进行。