tris((2-((4-trifluoromethyl)benzyl)phenylamino)ethyl)amine | 1148149-93-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris((2-((4-trifluoromethyl)benzyl)phenylamino)ethyl)amine
• 英文别名: N',N'-bis[2-[2-[[4-(trifluoromethyl)phenyl]methyl]anilino]ethyl]-N-[2-[[4-(trifluoromethyl)phenyl]methyl]phenyl]ethane-1,2-diamine
• CAS: 1148149-93-2
• 化学式: C₄₈H₄₅F₉N₄
• 分子量: 848.898
• InChiKey: WZOLSLWWEOPMSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.7
• 重原子数：
  61
• 可旋转键数：
  18
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.3
• 氢给体数：
  3
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 tris((2-((4-trifluoromethyl)benzyl)phenylamino)ethyl)amine 在 sodium tetrahydroborate 作用下， 以 水 、 溶剂黄146 、 乙腈 为溶剂， 反应 2.0h， 以95%的产率得到tris((2-((4-trifluoromethyl)benzyl)phenyl(methyl)amino)ethyl)amine
  参考文献：
  名称：

  One-pot synthesis of tripodal tris(2-aminoethyl)amine derivatives from seven molecular components

  摘要：

  Complex tripodal tris(2-aminoethyl)amine (tren)-based ligands have been prepared in a single-pot reaction of tren with 3 equiv each of cyclohexenone and a benzaldehyde derivative (i.e., from seven components and three molecular types). The highest yield of product was obtained for p-nitrobenzaldehyde, the most electrophilic aldehyde used. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.02.008
• 作为产物：
  描述：

  对三氟甲基苯甲醛 、 2-环己烯-1-酮 、 三(2-氨基乙基)胺 在 三乙烯二胺 、 苯甲酸 作用下， 以 甲苯 为溶剂， 反应 13.0h， 以18%的产率得到tris((2-((4-trifluoromethyl)benzyl)phenylamino)ethyl)amine
  参考文献：
  名称：

  One-pot synthesis of tripodal tris(2-aminoethyl)amine derivatives from seven molecular components

  摘要：

  Complex tripodal tris(2-aminoethyl)amine (tren)-based ligands have been prepared in a single-pot reaction of tren with 3 equiv each of cyclohexenone and a benzaldehyde derivative (i.e., from seven components and three molecular types). The highest yield of product was obtained for p-nitrobenzaldehyde, the most electrophilic aldehyde used. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.02.008

文献信息

• One-pot synthesis of tripodal tris(2-aminoethyl)amine derivatives from seven molecular components
  作者：Ann Almesåker、Janet L. Scott、Leone Spiccia、Christopher R. Strauss

  DOI：10.1016/j.tetlet.2009.02.008

  日期：2009.4

  Complex tripodal tris(2-aminoethyl)amine (tren)-based ligands have been prepared in a single-pot reaction of tren with 3 equiv each of cyclohexenone and a benzaldehyde derivative (i.e., from seven components and three molecular types). The highest yield of product was obtained for p-nitrobenzaldehyde, the most electrophilic aldehyde used. (C) 2009 Published by Elsevier Ltd.