(4R)-1-Boc-4-butoxy-L-proline | 356547-41-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R)-1-Boc-4-butoxy-L-proline
• 英文别名: (2S,4R)-4-butoxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
• CAS: 356547-41-6
• 化学式: C₁₄H₂₅NO₅
• 分子量: 287.356
• InChiKey: PMACEXFEMKWXCH-MNOVXSKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4R)-1-Boc-4-butoxy-L-proline 在 吡啶 、 盐酸 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  O-benzyl hydroxyproline as a bioisostere for Phe-Pro: Novel dipeptide thrombin inhibitors

  摘要：

  A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-ho dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00404-0
• 作为产物：
  描述：

  Boc-L-羟脯氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 以 二甲基亚砜 为溶剂， 生成 (4R)-1-Boc-4-butoxy-L-proline
  参考文献：
  名称：

  O-benzyl hydroxyproline as a bioisostere for Phe-Pro: Novel dipeptide thrombin inhibitors

  摘要：

  A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-ho dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00404-0

文献信息

• Macrocyclic Compounds And Methods Of Making And Using The Same
  申请人：Farmer J. Jay

  公开号：US20080045585A1

  公开（公告）日：2008-02-21

  The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

  本发明提供了一种用作治疗剂的大环化合物。更具体地说，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。
• MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Farmer Jay J.

  公开号：US20120252747A1

  公开（公告）日：2012-10-04

  The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R 1 , R 2 , R 3 , D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.

  本发明提供了通式为的大环化合物，可用作治疗剂，或其药学上可接受的盐、酯、N-氧化物或前药，其中T、R1、R2、R3、D、E、F和G如本文所定义。更具体地，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。
• MODULATEURS PEPTIDIQUES ET PEPTIDOMIMETIQUES NON COMPETITIFS SPECIFIQUES DE LA GLYCOPROTEINE P
  申请人：Centre National de la Recherche Scientifique CNRS

  公开号：EP2486007B1

  公开（公告）日：2013-07-03
• P-GLYCOPROTEIN-SPECIFIC NON-COMPETITIVE PEPTIDE AND PEPTIDOMIMETIC MODULATORS
  申请人：Arnaud Ophelie

  公开号：US20120309811A1

  公开（公告）日：2012-12-06

  The invention relates to a compound having structure (I), which acts as a non-competitive specific inhibitor of P-glycoprotein (P-gp for “Pleiotropic glycoprotein”) and which can be used as a drug, particularly for improving the effectiveness of chemotherapy treatments. The invention is therefore suitable for use in the medical field, particularly for the chemotherapeutic treatment of cancers or infections.
• US8841263B2
  申请人：——

  公开号：US8841263B2

  公开（公告）日：2014-09-23