levulinic acid vinyl ester | 98272-57-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: levulinic acid vinyl ester
• 英文别名: Laevulinsaeure-vinylester；Laevulinsaeurevinylester；Vinyl levulinate；ethenyl 4-oxopentanoate
• CAS: 98272-57-2
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: VEIVCESBDXEZQY-UHFFFAOYSA-N

物化性质

• 沸点：
  90-92 °C(Press: 15 Torr)
• 密度：
  1.016±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酸乙烯酯 、 乙酰丙酸 在 硫酸 作用下， 生成 levulinic acid vinyl ester
  参考文献：
  名称：

  Leonard, Industrial and Engineering Chemistry, 1956, vol. 48, p. 1331,1341

  摘要：

  DOI：

文献信息

• METHOD OF PRODUCING BICYCLO[3.1.0] HEXANE DERIVATIVE USING ENZYME
  申请人：HIROTSUKA Mitsuaki

  公开号：US20110065934A1

  公开（公告）日：2011-03-17

  Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.

  通过在微生物来源的酶存在下，通过将由式（II）表示的化合物与酰基供体反应转化为由式（III）表示的化合物的生产方法，可以生产出一种作为代谢型谷氨酸受体调节剂有用的脱氢脂肪酸衍生物，而无需使用昂贵的光学活性反式羟基酯作为起始物质，也无需进行需要超低温反应的氟化反应。此外，由于不对称合成可以在接近最终产品的阶段进行，因此该生产方法可作为一种可以大规模生产脱氢脂肪酸衍生物的生产方法。
• Ribonucleic acid compound and method of liquid-phase synthesis of oligonucleic acid compound
  申请人：Ohgi Tadaaki

  公开号：US20070172925A1

  公开（公告）日：2007-07-26

  A novel phosphotriesterified ribonucleic acid compound which is important for liquid-phase synthesis of oligo-RNA is provided. Examples of the ribonucleic acid compound of the invention may include ribonucleic acid compounds represented by the following general formula: (wherein B represents adenine, guanine, cytosine or uracil or a modified form thereof; R 21 represents aryl which may be substituted or a monocyclic or bicyclic heterocyclic group which may be substituted; R 20 represents H or alkyl which may be substituted; and R 1 represents a protecting group which can be removed at 90% or more at a temperature in the range from 0° C. to 60° C. under acidic conditions at a pH value from 2 to 4 within 24 hours).

  本发明提供了一种新型的磷酸三酯化核糖核酸化合物，对于寡核苷酸的液相合成非常重要。本发明的核糖核酸化合物的例子可能包括以下通式所代表的核糖核酸化合物：（其中B代表腺嘌呤、鸟嘌呤、胞嘧啶或尿嘧啶或其修饰形式；R21代表可以被取代的芳基或可以被取代的单环或双环杂环基团；R20代表氢或可以被取代的烷基；R1代表保护基，在pH值为2至4的酸性条件下，在24小时内在0℃至60℃的温度范围内可以去除90％或更多的保护基）。
• RIBONUCLEIC ACID COMPOUND AND METHOD OF LIQUID-PHASE SYNTHESIS OF OLIGONUCLEIC ACID COMPOUND
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1710249A1

  公开（公告）日：2006-10-11

  A novel phosphotriesterified ribonucleic acid compound which is important for liquid-phase synthesis of oligo-RNA is provided. Examples of the ribonucleic acid compound of the invention may include ribonucleic acid compounds represented by the following general formula: (wherein B represents adenine, guanine, cytosine or uracil or a modified form thereof; R21 represents aryl which may be substituted or a monocyclic or bicyclic heterocyclic group which may be substituted; R20 represents H or alkyl which may be substituted; and R1 represents a protecting group which can be removed at 90% or more at a temperature in the range from 0°C to 60°C under acidic conditions at a pH value from 2 to 4 within 24 hours).

  本发明提供了一种新型磷酸酯化核糖核酸化合物，该化合物对液相合成寡核糖核酸非常重要。 本发明的核糖核酸化合物可包括由以下通式表示的核糖核酸化合物： (其中 B 代表腺嘌呤、鸟嘌呤、胞嘧啶或尿嘧啶或其修饰形式；R21 代表可被取代的芳基或可被取代的单环或双环杂环基团；R20 代表 H 或可被取代的烷基；R1 代表保护基团，该保护基团可在 0°C 至 60°C 的温度范围内，在酸性条件下，在 pH 值为 2 至 4 的 24 小时内去除 90% 或以上）。
• METHOD OF PRODUCING BICYCLO[3.1.0]HEXANE DERIVATIVE USING ENZYME
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：EP2298755A1

  公开（公告）日：2011-03-23

  Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.

  生产双环[3.1.0]己烷衍生物可用作代谢型谷氨酸受体调节剂，其生产方法包括在微生物衍生酶存在下，通过与酰基供体反应，将式(II)代表的化合物转化为式(III)代表的化合物，而无需使用昂贵的光学活性反式羟基酯作为起始原料，也无需采用需要超低温反应的氟化反应。此外，由于不对称合成可在更接近最终产品的阶段进行，因此该生产方法可作为一种批量生产双环[3.1.0]己烷衍生物的生产方法。
• PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS
  申请人：PPG INDUSTRIES, INC.

  公开号：EP0613475B1

  公开（公告）日：1998-01-07