Ethane-1,2-diamine;3-methyl-2-(4-methylphenyl)sulfonylazanidylpentanoate;palladium(2+);hydrate | 1254592-72-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethane-1,2-diamine;3-methyl-2-(4-methylphenyl)sulfonylazanidylpentanoate;palladium(2+);hydrate
• CAS: 1254592-72-7
• 化学式: C₁₅H₂₅N₃O₄PdS*H₂O
• 分子量: 467.882
• InChiKey: LNRSOAWFLDQIKC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  对甲苯磺酰氯 在 水 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 10.5h， 生成 Ethane-1,2-diamine;3-methyl-2-(4-methylphenyl)sulfonylazanidylpentanoate;palladium(2+);hydrate
  参考文献：
  名称：

  Synthesis, characterization, and cytotoxicity of platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine

  摘要：

  Eight new platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine ligands, [Pd(en)(Tsile)]center dot H2O (1), [Pd(bipy)(Tsile)] (2), [Pd(bipy)(Tsthr)]center dot 0.5H2O (3), [Pd(phen)(Tsile)]center dot 0.5H2O (4), [Pd(phen)(Tsthr)]center dot H2O (5), [Pd(bqu)(Tsthr)]center dot 1.5H2O (6), [Pt(en)(Tsser)] (7), and [Pt(en)(Tsphe)]center dot H2O (8), have been synthesized and characterized by elemental analyses, 1H NMR and mass spectrometry. The crystal structure of 7 has been determined by X-ray diffraction. Cytotoxicities were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. The complexes exert cytotoxicity against HL-60, Bel-7402, BGC-823, and KB cell lines with 4 having the best cytotoxicity against HL-60, Bel-7402, and BGC-823 cell lines; the compounds are less cytotoxic than cisplatin.

  DOI：

  10.1080/00958972.2013.767447

文献信息

• Synthesis, characterization, and cytotoxicity of platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine
  作者：Luwei Li、Jinchao Zhang、Lili Ma、Zhilei Zhang、Shuxiang Wang、Shenghui Li、Guoqiang Zhou

  DOI：10.1080/00958972.2013.767447

  日期：2013.2.1

  Eight new platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine ligands, [Pd(en)(Tsile)]center dot H2O (1), [Pd(bipy)(Tsile)] (2), [Pd(bipy)(Tsthr)]center dot 0.5H2O (3), [Pd(phen)(Tsile)]center dot 0.5H2O (4), [Pd(phen)(Tsthr)]center dot H2O (5), [Pd(bqu)(Tsthr)]center dot 1.5H2O (6), [Pt(en)(Tsser)] (7), and [Pt(en)(Tsphe)]center dot H2O (8), have been synthesized and characterized by elemental analyses, 1H NMR and mass spectrometry. The crystal structure of 7 has been determined by X-ray diffraction. Cytotoxicities were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. The complexes exert cytotoxicity against HL-60, Bel-7402, BGC-823, and KB cell lines with 4 having the best cytotoxicity against HL-60, Bel-7402, and BGC-823 cell lines; the compounds are less cytotoxic than cisplatin.