3-acetoxy-1,1-cyclobutanedicarboxylic acid | 1140971-43-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-acetoxy-1,1-cyclobutanedicarboxylic acid
• 英文别名: 3-acetoxyl-1,1-cyclobutanedicarboxylate；3-Acetyloxycyclobutane-1,1-dicarboxylic acid
• CAS: 1140971-43-2
• 化学式: C₈H₁₀O₆
• 分子量: 202.164
• InChiKey: USASJGHENUOEFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-acetoxy-1,1-cyclobutanedicarboxylic acid 在 NaHCO₃ 作用下， 以 not given 为溶剂， 生成 cis-tetraammine-(μ-bis(3-acetoxy-1,1-cyclobutanedicarboxylato-κO1,O2))diplatinum(II) monohydrate
  参考文献：
  名称：

  Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex

  摘要：

  An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)(2)I-2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.

  DOI：

  10.1021/ic100638u
• 作为产物：
  描述：

  3-hydroxycyclobutane-1,1-dicarboxylic acid 、 乙酰氯 反应 4.0h， 生成 3-acetoxy-1,1-cyclobutanedicarboxylic acid
  参考文献：
  名称：

  Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex

  摘要：

  An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)(2)I-2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.

  DOI：

  10.1021/ic100638u

文献信息

• Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex
  作者：Mingjin Xie、Weiping Liu、Liguang Lou、Xizhu Chen、Qingsong Ye、Yao Yu、Qiaowen Chang、Shuqian Hou

  DOI：10.1021/ic100638u

  日期：2010.7.5

  An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)(2)I-2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.