4-bromo-benzenesulfonic acid-anhydride | 14248-47-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-benzenesulfonic acid-anhydride
• 英文别名: 4-Brom-benzolsulfonsaeure-anhydrid；p-Brom-benzolsulfonsaeure-anhydrid；4-Brom-benzolsulfonsaeure-(1)-anhydrid；p-Brombenzolsulfonsaeureanhydrid；(4-Bromophenyl)sulfonyl 4-bromobenzenesulfonate
• CAS: 14248-47-6
• 化学式: C₁₂H₈Br₂O₅S₂
• 分子量: 456.133
• InChiKey: KFCWJXULHYUQKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-bromo-benzenesulfonic acid-anhydride 在 氢溴酸 、 溶剂黄146 、 苯酚 作用下， 生成 4-二溴苯基二硫化物
  参考文献：
  名称：

  Lukaschevitsch, Doklady Akademii Nauk SSSR, 1955, vol. 103, p. 627,629

  摘要：

  DOI：
• 作为产物：
  描述：

  溴苯 在 硫酸 、 三氧化硫 作用下， 生成 4-bromo-benzenesulfonic acid-anhydride
  参考文献：
  名称：

  Lukaschewitsch, Doklady Akademii Nauk SSSR, 1954, vol. 99, p. 995,997

  摘要：

  DOI：

文献信息

• PROCESS FOR THE PREPARATION OF UNSATURATED CARBOXYLIC ACIDS BY CARBONYLATION OF ALLYL ALCOHOLS AND THEIR ACYLATION PRODUCTS
  申请人：BASF SE

  公开号：US20200055834A1

  公开（公告）日：2020-02-20

  The present invention relates to a process for carbonylating allyl alcohols at low temperature, low pressure and/or low catalyst loading. In an alternative embodiment, an acylation product of the allyl alcohol is used for the carbonylation. The present invention likewise relates to the preparation of conversion products of these carbonylation products and specifically of (−)-ambrox.

  本发明涉及一种在低温、低压和/或低催化剂负载下对烯丙醇进行羰基化的过程。在另一实施方式中，烯丙醇的酰化产物被用于羰基化。本发明还涉及制备这些羰基化产物的转化产物，特别是(−)-龙涎香。
• Process for the preparation of chiral azetidinones
  申请人：Framroze Patel Bomi

  公开号：US20070129540A1

  公开（公告）日：2007-06-07

  Processes for preparing compounds of formula I are disclosed comprising the steps of: (a) forming of chiral propionic acid ester compounds of formula V. (b) reacting compounds of formula V with aniline compounds to yield compounds of formula I

  公开了制备式I化合物的过程，包括以下步骤：(a)形成式V手性丙酸酯化合物。(b)将式V化合物与苯胺化合物反应，得到式I化合物。
• [EN] METHOD FOR THE ISOMERIZATION OF A 3-(Z)-UNSATURATED CARBOXYLIC ACID TO THE 3-(E)-ISOMER<br/>[FR] PROCÉDÉ D'ISOMÉRISATION D'UN ACIDE CARBOXYLIQUE 3-(Z)-INSATURÉ EN ISOMÈRE 3-(E)
  申请人：BASF SE

  公开号：WO2019158611A1

  公开（公告）日：2019-08-22

  The present invention relates to a method for isomerizing a 3-(Z)-unsaturated carboxylic acid of the formula l-Z or a salt thereof, wherein R2 is C1-C24-alkyl, C2-C24-alkenylhaving 1, 2, 3 or more than 3 C-C double bonds, unsubstituted or substituted C5-C12-cycloalkyl, or unsubstituted or substituted aryl; R1 is hydrogen or has one of the definitions specified for R2; with the proviso that R2 has a higher priority than R1 in accordance with lUPAC; to give a 3-(E)-unsaturated carboxylic acid of the formula I-E or a salt thereof, wherein the isomerization of the compound of the formula l-Z is effected in the presence of an anhydride of an organic acid and a base or in the presence of a ketene of formula CR11R12C(0), wherein R11 and R12 are as defined in the claims and in the specification and a base. In particular, the present invention relates to a method for preparing compositions with increased content of (3E, 7E)-homofarnesylic acid starting from compositions comprising (3Z,7E)- and (3E, 7E)-homofarnesylic acid.

  本发明涉及一种异构化3-(Z)-不饱和羧酸的方法，其化学式为l-Z或其盐，其中R2为C1-C24烷基，C2-C24烯基，具有1、2、3或多于3个C-C双键，未取代或取代的C5-C12环烷基或未取代或取代的芳基；R1为氢或具有R2指定的定义之一；在符合lUPAC的前提下，R2优先级高于R1，从而得到3-(E)-不饱和羧酸的化学式I-E或其盐。其中，在存在有机酸酐和碱或存在化学式为CR11R12C(0)的酮（其中R11和R12在权利要求和说明书中定义）和碱的情况下，对化合物l-Z进行异构化。特别地，本发明涉及一种制备含有增加的(3E,7E)-同型法尼酸的组合物的方法，其起始物为含有(3Z,7E)-和(3E,7E)-同型法尼酸的组合物。
• Process of making an alpha-anomer enriched 2-deoxy-2,2-diflouro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
  申请人：Wang Lung-Hu

  公开号：US20060276638A1

  公开（公告）日：2006-12-07

  A process of preparing an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate, which is useful as an intermediate in the preparation of a beta nucleoside, such as gemcitabine, an anti-tumor agent. A beta-2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate is heated and converted to an alpha-2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate in the absence of an effective amount of a sulfonate salt to facilitate the conversion. In addition, an anomeric mixture of an alpha-anomer and a beta-anomer of 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate can be dissolved in a mixture of water and a solvent and heated to produce a lactol, which may be further converted to an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate.

  一种制备α-异构体富集的2-脱氧-2,2-二氟-D-核糖磺酸酯的过程，该化合物可用作β-核苷类似物的中间体，例如抗肿瘤药物吉西他滨。将β-2-脱氧-2,2-二氟-D-核糖磺酸酯加热，并在无需有效量的磺酸盐的情况下将其转化为α-2-脱氧-2,2-二氟-D-核糖磺酸酯。此外，α-异构体和β-异构体的2-脱氧-2,2-二氟-D-核糖磺酸酯的反式混合物可溶于水和溶剂的混合物中，并加热以产生内酯，该内酯可进一步转化为富集α-异构体的2-脱氧-2,2-二氟-D-核糖磺酸酯。
• Method for 1H-Imidazo[4,5-C] Pyridines and Analogs Thereof
  申请人：Krepski Larry R.

  公开号：US20090240055A1

  公开（公告）日：2009-09-24

  Methods and intermediates for preparing compounds of the Formulas: (I and X) are disclosed. The methods include a method providing a compound of the Formula: (IV) and converting a compound of Formula IV to a compound of Formula I, a method providing a compound of the Formula: (VIII) and converting a compound of Formula VIII to a compound of Formula I, and a method providing a compound of the Formula: (XI) and converting a compound of Formula XI to a compound of Formula I.

  本文揭示了制备化合物公式(I和X)的方法和中间体。这些方法包括提供公式(IV)化合物并将公式IV化合物转化为公式I化合物的方法，提供公式(VIII)化合物并将公式VIII化合物转化为公式I化合物的方法，以及提供公式(XI)化合物并将公式XI化合物转化为公式I化合物的方法。