(2'-bromo-biphenyl-2-yl)-methanol | 13175-73-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2'-bromo-biphenyl-2-yl)-methanol
• 英文别名: 2-Brom-2'-hydroxy-methyl-biphenyl；2-Brom-2'-hydroxymethylbiphenyl；2-Bromo-2'-(Hydroxymethyl)biphenyl；[2-(2-bromophenyl)phenyl]methanol
• CAS: 13175-73-0
• 化学式: C₁₃H₁₁BrO
• 分子量: 263.134
• InChiKey: FTMVPYMRRCDAQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2'-bromo-biphenyl-2-yl)-methanol 在 氢溴酸 作用下， 生成 2'-Brom-2-brommethylbiphenyl
  参考文献：
  名称：

  磷杂环。第一部分共轭环状亚甲基磷烷

  摘要：

  环状季phospho盐9,10-二氢-9,9-二苯基-9-膦酰苯菲溴化物与氢氧化钠水溶液反应生成相应的环状亚甲基膦烷，其为不完全表征的橙色固体，与非环状相比，其相对水解的稳定性类似物，亚苄基三苯基磷烷，表明在含磷环中有一些芳香特性。

  DOI：

  10.1039/j39660002003
• 作为产物：
  描述：

  2,2'-双溴双苯 在 sodium tetrahydroborate 、 正丁基锂 作用下， 生成 (2'-bromo-biphenyl-2-yl)-methanol
  参考文献：
  名称：

  Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation

  摘要：

  Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library of bioactive compounds. By using multiple probes (hydroethidine, hydropropidine, Amplex Red, and coumarin boronate) with well defined redox chemistry that form highly diagnostic marker products upon reaction with superoxide (O2 arrange=stack.), hydrogen peroxide (H2O2), and peroxynitrite (ONOO-), the number of false positives was greatly decreased. Selected hits for Nox2 were further screened for their ability to inhibit ONOO- formation in activated macrophages. A new diagnostic marker product for ONOO- is reported. We conclude that the newly developed high throughput screening/reactive oxygen species assays could also be used to identify potential inhibitors of ONOO- formed from Nox2-derived O2. and nitric oxide synthase-derived nitric oxide.

  DOI：

  10.1074/jbc.m115.702787

文献信息

• Method of producing an o-disubstituted aromatic compound, and method of producing a monosubstituted-monohaloaromatic compound
  申请人：Yoshida Jun-ichi

  公开号：US20080194816A1

  公开（公告）日：2008-08-14

  A method of producing an o-disubstituted aromatic compound, containing: continuously conducting at least the following steps (a) to (d): (a) a step of mono-lithiating one halogen atom of an o-dihaloaromatic compound, using a first microreactor; (b) a step of making the thus-obtained monolithiated product to react with an electrophilic compound, using a second microreactor, to obtain a monosubstituted-monohaloaromatic compound; (c) a step of lithiating the other halogen atom of the o-dihaloaromatic compound, using a third microreactor; and (d) a step of making the thus-obtained lithiated product successively to react with an electrophilic compound, using a forth microreactor.

  生产 o-二取代芳香化合物的方法，包括：连续进行至少以下步骤（a）至（d）： (a) 使用第一微反应器对 o-二卤代芳香化合物的一个卤原子进行单锂化步骤； (b) 使用第二微反应器使得所得的单锂化产物与亲电性化合物发生反应，以获得单取代-单卤代芳香化合物的步骤； (c) 使用第三微反应器对 o-二卤代芳香化合物的另一个卤原子进行锂化步骤；以及 (d) 使用第四微反应器使得所得的锂化产物依次与亲电性化合物发生反应的步骤。
• KO^tBu mediated efficient approach for the synthesis of fused heterocycles via intramolecular O-/N-arylations
  作者：Raju Singha、Atiur Ahmed、Yasin Nuree、Munmun Ghosh、Jayanta K. Ray

  DOI：10.1039/c5ra07532g

  日期：——

  KO^tBu mediated an efficient methodology has been developed for the synthesis of 6H-benzo[c]chromenes, 6H-benzo[c]chromen-6-ones, carbazoles, dibenzofurans and dibenzooxepins.

  KOtBu介导的高效方法已被开发用于合成6H-苯并[c]色酮，6H-苯并[c]色酮-6-酮，咔唑，二苯并呋喃和二苯并氧杂环戊二烯。
• Phosphorus heterocycles. Part I. A conjugated cyclic methylenephosphorane
  作者：E. A. Cookson、P. C. Crofts

  DOI：10.1039/j39660002003

  日期：——

  The cyclic quaternary phosphonium salt 9,10-dihydro-9,9-diphenyl-9-phosphoniaphenanthrene bromide reacts with aqueous sodium hydroxide to give the corresponding cyclic methylenephosphorane as an incompletely characterised orange solid, the relative stability towards hydrolysis of which compared with its acyclic analogue, benzylidenetriphenylphosphorane, suggests some aromatic character in the phosphorus-containing

  环状季phospho盐9,10-二氢-9,9-二苯基-9-膦酰苯菲溴化物与氢氧化钠水溶液反应生成相应的环状亚甲基膦烷，其为不完全表征的橙色固体，与非环状相比，其相对水解的稳定性类似物，亚苄基三苯基磷烷，表明在含磷环中有一些芳香特性。
• [EN] CHIRAL TERTIARY AMINOALKYLNAPHTHOLS<br/>[FR] AMINOALKYLNAPHTOLS CHIRAUX TERTIAIRES
  申请人：UNIV HONG KONG POLYTECHNIC

  公开号：WO2005087707A1

  公开（公告）日：2005-09-22

  The invention relates to the compounds of formula: (I) which are as defined in the specification. Their use as chiral ligands in catalytic aryl transfer reactions to aromatic aldehydes is also described.

  该发明涉及以下化合物的公式：(I)，其在说明书中定义。还描述了它们作为手性配体在催化芳基转移反应中对芳香醛的使用。
• Chiral Tertiary Aminoalkylnaphthols
  申请人：Chan Albert Sun-Chi

  公开号：US20080045757A1

  公开（公告）日：2008-02-21

  The invention relates to the compounds of formula: (I) which are as defined in the specification. Their use as chiral ligands in catalytic aryl transfer reactions to aromatic aldehydes is also described.

  本发明涉及化合物的公式：（I），其在规范中定义。还描述了它们作为手性配体在催化芳基转移反应中对芳香醛的使用。