2-amino-4-ethoxyphenol | 40140-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-amino-4-ethoxyphenol
• CAS: 40140-99-6
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: JYQPIZUBNCCGFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-4-ethoxyphenol 生成 1-acetoxy-2-acetylamino-4-ethoxy-benzene
  参考文献：
  名称：

  DE670584

  摘要：

  公开号：
• 作为产物：
  描述：

  2,5-二乙氧基苯胺 在 三氯化铝 、 苯胺 作用下， 生成 2-amino-4-ethoxyphenol
  参考文献：
  名称：

  DE670584

  摘要：

  公开号：

文献信息

• Antiviral agent
  申请人：——

  公开号：US20040229909A1

  公开（公告）日：2004-11-18

  The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. 1 (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH; R A is a group shown by 2 (wherein, C ring is N-containing aromatic heterocycle) or the like)

  本发明提供了一种整合酶抑制剂。发明人发现以下化合物具有整合酶抑制活性，其化学式为(I)。其中，RC和RD与相邻的碳原子一起形成一个环，该环可以是一个缩合环，Y是羟基，巯基或氨基; Z是O，S或NH; RA是由2所示的基团（其中，C环是含N的芳香杂环）或类似基团。
• METAL CHELATE AZO DYE FOR INK-JET RECORDING, INK-JET RECORDING FLUID CONTAINING THE SAME, AND METHOD OF INK-JET RECORDING
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP1260556A1

  公开（公告）日：2002-11-27

  The present invention provides a black dyestuff for inkjet recording which exhibits a good achromaticity as well as a good light-resistance and a recording liquid containing the black dyestuff. In other words, the recording liquid for inkjet contains a metal chelated azo dyestuff the free acid group of which is represented by the following general formula (1) and optionally other water soluble dyestuffs: (wherein the general formula (1) represents a compound having at least one or more hydrophilic group per molecule; M represents an arbitrary metal; A, B and C each independently represents an aromatic ring which may have arbitrary substituents; D represents an aromatic ring which may have arbitrary substituents other than azo group; m represents an integer of 0 to 1; n represents an integer of from 0 to 3; p represents an integer of from 0 to 2; q represents an integer of from 1 to 3, with the proviso that if there are a plurality of B's, they may be the same or different; R1 and R2 each independently represents hydrogen atom or arbitrary substituent; M can take tridentate or higher coordination in which M may take arbitrary ligand-to-metal coordination at arbitrary substituent or bond in the general formula (1) or with arbitrary ligands; and a metal ion may be further coordinated to A and B, B and B which are adjacent to each other with an azo group interposed therebetween if there are a plurality of B's or B and C in the form of -O-M-O-).

  本发明提供了一种具有良好消色差和耐光性的喷墨记录用黑色染料，以及一种含有该黑色染料的记录液。 换句话说，喷墨记录液含有一种金属螯合偶氮染料，其游离酸基由以下通式（1）表示，还可选择其他水溶性染料： (其中，通式（1）代表每分子至少有一个或多个亲水基团的化合物；M 代表任意金属；A、B 和 C 各自独立地代表一个芳香环，该芳香环可以有任意取代基；D 代表芳香环，可具有除偶氮基团以外的任意取代基； m 代表 0 至 1 的整数； n 代表 0 至 3 的整数； p 代表 0 至 2 的整数； q 代表 1 至 3 的整数，但如果有多个 B，它们可以相同或不同；R1和R2各自独立地代表氢原子或任意取代基；M可以是三叉配位或更高配位，其中M可以在通式（1）中的任意取代基或键上进行任意配体对金属配位或与任意配体配位；如果有多个B或B和C以-O-M-O-的形式存在，金属离子可以进一步与A和B配位，B和B相邻，中间夹有偶氮基团。）
• Antiviral Agent
  申请人：SHIONOGI & CO., LTD.

  公开号：EP2181985A1

  公开（公告）日：2010-05-05

  The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, RC and RD taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; RA is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)

  本发明提供了一种整合酶抑制剂。本发明者发现了以下具有整合酶抑制活性的式 (I) 化合物。 (其中，RC 和 RD 与邻近的碳原子共同形成一个环，该环可以是缩合环；Y 是羟基、巯基或氨基；Z 是 O、S 或 NH； RA 是以下所示的基团 (其中，C 环为含 N 的芳香杂环）或类似物）。
• SUBSTITUENT-INCLUDING UREA COMPOUND
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3915558A1

  公开（公告）日：2021-12-01

  An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases. The present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. (Each symbol in Formula (1) has the same definition as that described in the specification.)

  本发明的目的是提供一种化合物，该化合物具有特定的化学结构，对 SIRT6 具有激活作用，可作为预防和治疗炎症性疾病的活性成分。本发明涉及一种由式（1）代表的化合物或其药学上可接受的盐。 式（1）中各符号的定义与说明书中所述的相同）。
• Metal chelated azo dyestuff for inkjet recording and recording liquid for inkjet and inkjet recording method using same
  申请人：Mitsubishi Chemical Corporation

  公开号：US20030149251A1

  公开（公告）日：2003-08-07

  The present invention provides a black dyestuff for inkjet recording which exhibits a good achromaticity as well as a good light-resistance and a recording liquid containing the black dyestuff. In other words, the recording liquid for inkjet contains a metal chelated azo dyestuff the free acid group of which is represented by the following general formula (1) and optionally other water soluble dyestuffs: 1 (wherein the general formula (1) represents a compound having at least one or more hydrophilic group per molecule; M represents an arbitrary metal; A, B and C each independently represents an aromatic ring which may have arbitrary substituents; D represents an aromatic ring which may have arbitrary substituents other than azo group; m represents an integer of 0 to 1; n represents an integer of from 0 to 3; p represents an integer of from 0 to 2; q represents an integer of from 1 to 3, with the proviso that if there are a plurality of B's, they may be the same or different; R 1 and R 2 each independently represents hydrogen atom or arbitrary substituent; M can take tridentate or higher coordination in which M may take arbitrary ligand-to-metal coordination at arbitrary substituent or bond in the general formula (1) or with arbitrary ligands; and a metal ion may be further coordinated to A and B, B and B which are adjacent to each other with an azo group interposed therebetween if there are a plurality of B's or B and C in the form of —O-M-O—).

  本发明提供了一种具有良好消色差和耐光性的喷墨记录用黑色染料，以及一种含有该黑色染料的记录液。 换句话说，喷墨记录液含有一种金属螯合偶氮染料，其游离酸基由以下通式（1）表示，还可选择其他水溶性染料： 1 (其中通式(1)代表每分子至少有一个或多个亲水基团的化合物；M 代表任意金属；A、B 和 C 各自独立地代表一个芳香环，该芳香环可以有任意取代基；D 代表一个芳香环，该芳香环可以有偶氮基以外的任意取代基；m 代表 0 至 1 的整数；n 代表 0 至 3 的整数；p 代表 0 至 2 的整数；q 代表 1 至 3 的整数，但如果有多个 B，它们可以相同或不同；R 1 和 R 2 各自独立地代表氢原子或任意取代基；M 可以是三叉配位或更高配位，其中 M 可以在通式（1）中的任意取代基或键上进行任意配体对金属配位，或与任意配体配位；如果有多个 B 或以 -O-M-O- 形式存在的 B 和 C，金属离子可进一步与 A 和 B、相邻的 B 和 B 之间的偶氮基配位。）