5-(氯甲基)-2-甲氧基苯甲酸甲酯 | 7252-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-(氯甲基)-2-甲氧基苯甲酸甲酯
• 英文名称: 3-carbomethoxy-4-methoxybenzyl chloride
• 英文别名: methyl 2-methoxy-5-chloromethylbenzoate；5-chloromethyl-2-methoxy-benzoic acid methyl ester；5-Chlormethyl-2-methoxy-benzoesaeure-methylester；Methyl-2-methoxy-5-chlormethylbenzoat；methyl 5-(chloromethyl)-2-methoxybenzoate
• CAS: 7252-24-6
• 化学式: C₁₀H₁₁ClO₃
• 分子量: 214.649
• InChiKey: VYBQOEVRXJJHTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(氯甲基)-2-甲氧基苯甲酸甲酯 生成 苯乙腈
  参考文献：
  名称：

  N,N'-bis[3-substituted-4-hydroxypheyl)-2-hydroxyethyl)]

  摘要：

  N,N'-双[2-(3-取代-4-羟基苯基)-乙基或-2-羟基乙基]-聚甲基二胺具有β-肾上腺素刺激活性，特别作为选择性支气管扩张剂。通常通过N-苄基苯乙胺与聚甲烯二卤化物的缩合或α-溴代苯乙酮与N,N'-双苄基-聚甲基二胺的反应制备，随后根据3-取代基的性质进行进一步操作，最后进行例如钯-碳上的催化氢化。关键中间体也是该发明的一部分。

  公开号：

  US03933913A1
• 作为产物：
  描述：

  5-甲酰基-2-甲氧基苯甲酸甲酯 在 sodium tetrahydroborate 、 氯化亚砜 作用下， 以 甲醇 为溶剂， 生成 5-(氯甲基)-2-甲氧基苯甲酸甲酯
  参考文献：
  名称：

  Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARα-selective activators

  摘要：

  A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the alpha -position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR trans activation. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00672-2

文献信息

• A simple and inexpensive procedure for chloromethylation of certain aromatic compounds
  作者：Alexander McKillop、Fereidon Abbasi Madjdabadi、David A. Long

  DOI：10.1016/s0040-4039(00)81809-2

  日期：1983.1

  Reaction of a range of aromatic compounds with methoxyacetyl chloride and aluminium chloride in either nitromethane or carbon disulphide results in chloromethylation in good to excellent yield.

  一系列芳族化合物与甲氧基乙酰氯和氯化铝在硝基甲烷或二硫化碳中的反应导致氯甲基化，收率好至极佳。
• Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
  申请人：Aventis Pharmaceuticals Inc.

  公开号：US06211199B1

  公开（公告）日：2001-04-03

  The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

  本发明涉及一种新型的取代哌啶衍生物，其化学式为（1），其立体异构体以及药学上可接受的盐，这些衍生物可用作组胺受体拮抗剂和速激肽受体拮抗剂。这些拮抗剂在过敏性鼻炎的治疗中很有用，包括季节性鼻炎和鼻窦炎；炎症性肠病，包括克罗恩病和溃疡性结肠炎；哮喘；支气管炎；以及呕吐。
• Novel substituted 4-(1H-benzimidazol-2-yl) [1,4]diazepanes useful for the treatment of allergic diseases
  申请人：——

  公开号：US20010034343A1

  公开（公告）日：2001-10-25

  The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula 1 and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

  本发明涉及一种新颖的4-(1H-苯并咪唑-2-基)[1,4]二氮杂环庚烷衍生物及其立体异构体，以及其药学上可接受的盐，其作为组胺受体拮抗剂和速激肽受体拮抗剂具有用途。这些拮抗剂在过敏性鼻炎的治疗中有用，包括季节性鼻炎和鼻窦炎；炎症性肠病，包括克罗恩病和溃疡性结肠炎；哮喘；支气管炎；以及呕吐。
• Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
  申请人：Aventis Pharmaceuticals Inc.

  公开号：US06194406B1

  公开（公告）日：2001-02-27

  The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

  本发明涉及新颖的4-(1H-苯并咪唑-2-基)[1,4]二氮杂环庚烷衍生物的化合物（1）及其立体异构体，以及其药学上可接受的盐，这些化合物可用作组胺受体拮抗剂和速激肽受体拮抗剂。这些拮抗剂在过敏性鼻炎的治疗中很有用，包括季节性鼻炎和鼻窦炎；炎症性肠病，包括克罗恩病和溃疡性结肠炎；哮喘；支气管炎；以及呕吐。
• Silver halide emulsion and silver halide photographic light-sensitive material
  申请人：Suzuki Hiroyuki

  公开号：US20050048424A1

  公开（公告）日：2005-03-03

  A silver halide emulsion chemically sensitized by a compound of formula (1), (6-1), (6-2) or (7); and a silver halide photographic light-sensitive material containing the silver halide emulsion: Formula (1) E 1 -Ch-E 2 Formula (6-1) W 1 . . .AuX 2 m Formula (6-2) [W 1 . . . Au. . . W 2 ]X 2 m Formula (7) E 5 -Ch-Au . . . (L 2 ) 1 wherein Ch is a sulfur, selenium or tellurium atom; E 1 , E 2 and E 5 each are, for example, a specific methylene group having a substituent; Au is a monovalent or trivalent gold ion; W 1 and W 2 each are a specific chalcogen compound; X 2 is a monovalent anion; m is 1, 2 or 3; L 2 is a compound that can coordinate with gold through a nitrogen, sulfur, selenium, tellurium or phosphorous atom; and 1 is 0, 1, 2 or 3.

  一种由公式（1）、（6-1）、（6-2）或（7）的化合物进行化学增敏的银卤化物乳剂；以及一种含有该银卤化物乳剂的银卤化物感光材料：公式（1）E1-Ch-E2；公式（6-1）W1. . .AuX2m；公式（6-2）[W1. . . Au. . . W2]X2m；公式（7）E5-Ch-Au . . .（L2）1其中，Ch是硫、硒或碲原子；E1、E2和E5分别是具有取代基的特定亚甲基基团；Au是单价或三价金离子；W1和W2是特定的硫族化合物；X2是单价阴离子；m为1、2或3；L2是一种可以通过氮、硫、硒、碲或磷原子与金配位的化合物；1为0、1、2或3。