Glykolsaeure-(4-nitro-benzylester) | 15396-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Glykolsaeure-(4-nitro-benzylester)
• 英文别名: Glykolsaeure-(4-nitrobenzylester)；Glykolsaeure-p-nitrobenzylester；4-Nitrobenzyl hydroxyacetate；(4-nitrophenyl)methyl 2-hydroxyacetate
• CAS: 15396-82-4
• 化学式: C₉H₉NO₅
• 分子量: 211.174
• InChiKey: ATSBCYCDWHNQOD-UHFFFAOYSA-N

物化性质

• 熔点：
  107-108 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  378.8±22.0 °C(Predicted)
• 密度：
  1.393±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Glykolsaeure-(4-nitro-benzylester) 在 氢溴酸 、 溶剂黄146 作用下， 生成 O--glykolsaeure-<4-nitro-benzylester>
  参考文献：
  名称：

  Depsipeptide analogs of biologically active peptides

  摘要：

  DOI：

  10.1007/bf00845310
• 作为产物：
  描述：

  tert.-Butoxy-essigsaeure-(4-nitro-benzylester) 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 生成 Glykolsaeure-(4-nitro-benzylester)
  参考文献：
  名称：

  Wasielewski,C., Roczniki Chemii, 1966, vol. 40, p. 1443 - 1447

  摘要：

  DOI：

文献信息

• Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime
  申请人：Roussel Uclaf

  公开号：US05183896A1

  公开（公告）日：1993-02-02

  Compounds of the formula ##STR1## which have a long-lasting cholinomimetic activity by oral route. Also disclosed are methods for preparing the compounds and pharmaceutical compositions containing the compounds.

  该公式的化合物##STR1## 通过口服具有长效的胆碱样作用。还公开了制备该化合物的方法和含有该化合物的药物组合物。
• 6-substituted penem compounds
  申请人：Ciba-Geigy Corporation

  公开号：US04692442A1

  公开（公告）日：1987-09-08

  The invention relates to 2-penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.a represents an organic radical bonded by a carbon atom to the ring carbon atom, a free, etherified or esterified hydroxy or mercapto group or a halogen atom, R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom, or an etherified mercapto group, and R.sub.2 represents a hydroxy group or an R.sub.2.sup.A radical that together with the carbonyl grouping --C(.dbd.O)-- forms a protected carboxyl group, and to salts of such compounds with salt-forming groups, processes for the manufacture of such compounds, pharmaceutical preparations containing compounds of the formula I with pharmacological properties, and their use. The compounds have antibiotic activity.

  本发明涉及公式为##STR1##的2-青霉烷-3-羧酸化合物，其中R.sub.a代表有机基团，通过碳原子与环碳原子结合，自由的，醚化或酯化的羟基或巯基，或卤素原子，R.sub.1代表氢，通过碳原子与环碳原子结合的有机基团，或醚化的巯基，R.sub.2代表羟基或R.sub.2.sup.A基团，与羰基--C(.dbd.O)--一起形成保护的羧基基团，以及具有盐基团的这样的化合物的盐，制备这样的化合物的过程，含有公式I的化合物的药物制剂，以及它们的用途。这些化合物具有抗生素活性。
• 6-substituted thia-aza compounds
  申请人：Ciba-Geigy Corporation

  公开号：US04952690A1

  公开（公告）日：1990-08-28

  The invention relates to azetidin-2-ones of the formula ##STR1## wherein R.sub.a represents hydroxy-lower alkyl, R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group, R.sub.2.sup.A together with the carbonyl group to which it is attached is a protected carboxyl group and Z' is oxygen, sulfhur or an optionally substituted methylidene group, functional groups in the radicals R.sub.a, R.sub.1 and Z' optionally being in protected form. The azetidinones are useful intermediates for the preparation of penem antibiotics.

  本发明涉及公式为##STR1##的氮杂四元酮，其中R.sub.a代表羟基-低碳基，R.sub.1代表氢，有机基团通过碳原子与环碳原子键合或醚化的巯基团，R.sub.2.sup.A与其所附的羰基团一起是受保护的羧基团，Z'是氧、硫或可选取代的甲基亚烯基团，基团R.sub.a、R.sub.1和Z'中的官能团可选择处于保护形式。这些氮杂四元酮是制备青霉烷类抗生素的有用中间体。
• Novel carbapenem derivatives
  申请人：——

  公开号：US20040038967A1

  公开（公告）日：2004-02-26

  An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof: 1 wherein R 1 represents H or methyl, R 2 and R 3 each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.

  本发明的目标是提供对MRSA、PRSP、流感病毒和β-内酰胺酶产生细菌具有强抗生素活性且稳定于DHP-1的头孢烯类衍生物。本发明的头孢烯类衍生物是由式(I)和(II)或其药学上可接受的盐所表示的化合物：其中R1代表H或甲基，R2和R3各自独立地代表H、卤素、取代或未取代的烷基、环烷基、取代或未取代的烷基羰基、氨基甲酰基、取代或未取代的芳基、取代或未取代的烷基硫代基、吗啉基、烷基磺酰基或甲酰基，n为0到4，Hy代表取代或未取代的单环或双环杂环基团。
• NOVEL CARBAPENEM DERIVATIVES
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1336612B1

  公开（公告）日：2007-01-17