1-[2-(三氟甲基)苯基]丙-2-胺 | 670-04-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[2-(三氟甲基)苯基]丙-2-胺
• 英文名称: PAL-307
• 英文别名: 1-(2-trifluoromethylphenyl)-2-aminopropane；2-Amino-1-(2-trifluormethyl-phenyl)-propan；2-Amino-1-(3-trifluormethyl-phenyl)-propan；1-(2-Trifluormethylphenyl)-2-aminopropan；1-(2-(Trifluoromethyl)phenyl)-2-aminopropane；1-[2-(trifluoromethyl)phenyl]propan-2-amine
• CAS: 670-04-2
• 化学式: C₁₀H₁₂F₃N
• mdl: MFCD01708016
• 分子量: 203.207
• InChiKey: MBSQCJRYAIIWCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  1-[2-(三氟甲基)苯基]丙-2-胺 、 以 氘代氯仿 为溶剂， 生成
  参考文献：
  名称：

  Detection and identification of amphetamine-type stimulants and analogs via recognition-enabled “chromatographic” 19F NMR

  摘要：

  DOI：

  10.1016/j.jfluchem.2023.110085
• 作为产物：
  描述：

  邻三氟甲基苯甲醛 在 lithium aluminium tetrahydride 、 正丁胺 作用下， 生成 1-[2-(三氟甲基)苯基]丙-2-胺
  参考文献：
  名称：

  厌氧剂：芳香族取代的1-苯基-2-丙烯酰胺。

  摘要：

  DOI：

  10.1021/jm00341a011

文献信息

• N-substituted glycinates
  申请人：Science Union et Cie, Societe Francaise de Recherche Medical

  公开号：US03956501A1

  公开（公告）日：1976-05-11

  N-substituted glycinates of the formula: ##EQU1## optical isomers and acid addition salts thereof, wherein R is cyclopentyl, cyclohexyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl, methylenedioxybenzyl or trifluoromethylbenzyl. These compounds are used as medicines especially in the treatment of obesity or other metabolic diseases needing weight reduction and regulation.

  N-取代的甘氨酸盐的化学式为：##EQU1## 其光学异构体和酸盐，其中R为环戊基、环己基、苄基、卤代苄基、较低烷基苄基、较低烷氧基苄基、亚甲二氧基苄基或三氟甲基苄基。这些化合物被用作药物，特别用于治疗肥胖或其他需要减重和调节的代谢性疾病。
• METHOD FOR TREATING EPILEPSY
  申请人：Xenon Pharmaceuticals Inc.

  公开号：US20200030260A1

  公开（公告）日：2020-01-30

  In certain embodiments, the present disclosure is directed to methods and uses for treating a mammal having an epileptic seizure disorder or being at risk for having an epileptic seizure disorder, comprising administering certain herein disclosed isolated fenfluramine enantiomers that are surprisingly effective as anti-epilepsy drugs (AEDs), despite having lower anti-seizure potency than fenfluramine racemate, by virtue of also being less cardiotoxic than fenfluramine racemate. Preferred embodiments contemplate treatment of Dravet syndrome; other preferred embodiments contemplate treatment of other epileptic seizure disorders.

  在某些实施方式中，本公开涉及针对患有癫痫发作障碍或处于患有癫痫发作障碍风险的哺乳动物进行治疗的方法和用途，包括给予某些在此处披露的孤立芬氟拉明对映体，尽管其抗癫痫效力低于芬氟拉明混合物，但由于其心脏毒性也低于芬氟拉明混合物，因此这些对映体出奇地有效作为抗癫痫药物（AEDs）。优选实施方式考虑特拉维特综合征的治疗；其他优选实施方式考虑其他癫痫发作障碍的治疗。
• Novel aminotransferase, gene encoding the same, and method of using them
  申请人：Ito Noriyuki

  公开号：US20100285544A1

  公开（公告）日：2010-11-11

  The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or transformant. The aminotransferase of the invention has an ability of efficiently converting a ketone compound, particularly a cyclic ketone compound to an optically active amino compound. According to the invention, a method for efficiently producing an optically active amino compound, particularly an optically active cyclic amino compound is provided.

  本发明涉及一种新型氨基转移酶、编码该酶的DNA、已引入该DNA的重组载体以及已引入该载体的转化菌株。此外，本发明还涉及一种利用该酶或转化菌株生产光学活性氨基化合物的方法。本发明的氨基转移酶能够高效地将酮类化合物，尤其是环状酮类化合物转化为光学活性氨基化合物。根据本发明，提供了一种高效生产光学活性氨基化合物，尤其是光学活性环状氨基化合物的方法。
• Producing optically active amino compounds
  申请人：Kaneka Corporation

  公开号：US20020192786A1

  公开（公告）日：2002-12-19

  To provide a method for preparing optically active compounds, which mainly contain (R)-amino compounds, by microbial enzymes efficiently and inexpensively; a polypeptide having stereoselective transaminase activity which can be suitably used for the above preparation method; and a DNA encoding the polypeptide. A method for preparing an optically active amino compound, characterized in stereoselectively transaminating by acting a transaminase on an amino group acceptor, a ketone compound in the presence of an amino group donor, a primary amine; a DNA comprising a nucleotide sequence encoding a polypeptide having stereoselective transaminase activity; and a polypeptide having stereoselective transaminase activity obtainable from a culture of a microorganism belonging to the genus Arthrobacter.

  提供一种通过微生物酶高效、低成本地制备主要含有(R)-氨基化合物的手段；一种具有立体选择性转氨酶活性的多肽，适用于上述制备方法；以及编码该多肽的DNA。一种制备光学活性氨基化合物的方法，其特征在于，在存在氨基供体——一种初级胺的情况下，通过作用转氨酶对氨基受体进行立体选择性转氨，将酮化合物转化为目标化合物；一种包含编码具有立体选择性转氨酶活性的多肽的核苷酸序列的DNA；以及从属于芽孢杆菌属的微生物培养物中获得的具有立体选择性转氨酶活性的多肽。
• Process for producing optically active amino compounds
  申请人：Kaneka Corporation

  公开号：US20010031487A1

  公开（公告）日：2001-10-18

  The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.

  制备光学活性(R)-氨基化合物的方法特征在于，在(R)-型特异性转氨酶的作用下，在酮化合物（氨基受体）和一个外消旋或(R)-型的氨基化合物（氨基供体）的共存下，立体选择性地进行氨基基团转移，从而获得光学活性(R)-氨基化合物。根据本发明，可以轻松高产地制备传统上难以制备的在其1-位置具有芳基等基团的光学活性(R)-氨基化合物等。