2,2-dimethyl-octadecanoic acid amide | 699011-92-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-dimethyl-octadecanoic acid amide
• 英文别名: 2,2-Dimethyl-octadecansaeure-amid；Dimethylstearamide；2,2-dimethyloctadecanamide
• CAS: 699011-92-2
• 化学式: C₂₀H₄₁NO
• 分子量: 311.552
• InChiKey: PCLXYPMMZJNFEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-octadecanoic acid amide 在 nitrosylsulfuric acid 、 硫酸 作用下， 生成 2,2-dimethyloctadecanoic acid
  参考文献：
  名称：

  Buu-Hoi; Cagniant, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1943, vol. 279, p. 76,83

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-dimethyloctadecanoyl chloride 在 ammonium hydroxide 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 2,2-dimethyl-octadecanoic acid amide
  参考文献：
  名称：

  酰基辅酶A：胆固醇酰基转移酶（ACAT）的抑制剂。2.修饰脂肪酸苯胺ACAT抑制剂：酰胺键的生物等位取代。

  摘要：

  为了进一步定义在体外有效抑制酰基辅酶A：胆固醇酰基转移酶（ACAT）和体内降低胆固醇所必需的结构特征，在我们先前确定的脂肪酸苯胺类ACAT系列中，对酰胺键的生物等位取代进行了系统的研究进行抑制剂。仅用具有氢键供体和受体功能的异构酶替代酰胺键，得到保留ACAT抑制活性的化合物。用尿素生物甾体取代酰胺键产生的化合物在体外是有效的ACAT抑制剂，在体内是有效的降胆固醇药。检查N-苯基-N'-烷基脲的苯环和烷基部分的结构活性关系发现，在苯环中6-二异丙基取代是最佳的。当2，6-二异丙基部分保持恒定时，在体外和体内的效力通过长度为6至18个碳的直链和支链烷基保持。

  DOI：

  10.1021/jm00063a016

文献信息

• Associative thickeners for aqueous systems
  申请人：Lai Ta-Yuan John

  公开号：US20060039939A1

  公开（公告）日：2006-02-23

  Thiocarbonate compounds which, in one embodiment, are utilized as a rheology modifier or associative thickener. The thiocarbonate compounds thicken or increase the viscosity of a composition, preferably an aqueous composition when used in an effective amount. In one preferred embodiment, the thiocarbonate compounds include at least one hydrophilic group containing repeat unit such as derived from acrylic acid, and at least one hydrophobic group to enhance association with other compounds and thus increase viscosity of a composition. Aqueous composition comprising a latex and thiocarbonate associative thickeners are described.

  Thiocarbonate化合物在一种实施方式中被用作流变改性剂或联合增稠剂。当以有效量使用时，这些thiocarbonate化合物可以增稠或增加组成物的粘度，特别是水性组成物。在一个优选实施方式中，这些thiocarbonate化合物包括至少一个亲水基团重复单元，例如来自丙烯酸，并且至少一个疏水基团，以增强与其他化合物的结合，从而增加组成物的粘度。描述了包含乳胶和thiocarbonate联合增稠剂的水性组成物。
• Shampoo containing a gel network
  申请人：The Procter & Gamble Company

  公开号：US20030223952A1

  公开（公告）日：2003-12-04

  The compositions of the present invention relate to improved shampoo compositions having from about from about 5 to about 50 weight percent of a detersive surfactant, at least about 0.05 weight percent of a fatty alcohol gel network and at least about 20.0 weight percent of an aqueous carrier.

  本发明的组合物涉及改进的洗发水组合物，其含有约5至50重量％的去污表面活性剂，至少约0.05重量％的脂肪醇凝胶网络和至少约20.0重量％的水基载体。
• Multi-purpose polymers, methods and compositions
  申请人：——

  公开号：US20040241130A1

  公开（公告）日：2004-12-02

  Disclosed are multi-purpose polymers that are the polymerization product of a monomer mixture comprising at least one amino-substituted vinyl monomer; at least one nonionic vinyl monomer; at least one associative vinyl monomer; at least one semihydrophobic vinyl surfactant monomer; and, optionally, comprising one or more hydroxy-substituted nonionic vinyl monomer, crosslinking monomer, chain transfer agent or polymeric stabilizer. These vinyl addition polymers have a combination of substituents, including amino substituents that provide cationic properties at low pH, hydrophobic substituents, hydrophobically modified polyoxyalkylene substituents, and hydrophilic polyoxyalkylene substituents. The polymers provide surprisingly beneficial Theological properties in acidic aqueous compositions, and are compatible with cationic materials. Additionally, this invention relates to the incorporation of a basic material after the addition of an acidic material to reduce the pH of the composition without negatively impacting the viscosity of the composition. The multi-purpose polymers are useful in a variety of products for personal care, health care, household care, institutional and industrial care, and industrial applications.

  本发明涉及多用途聚合物，其为单体混合物的聚合物化产物，包括至少一种氨基取代的乙烯单体；至少一种非离子乙烯单体；至少一种联合乙烯单体；至少一种半亲水性乙烯表面活性剂单体；以及可选地包括一种或多种羟基取代的非离子乙烯单体、交联剂、链转移剂或聚合稳定剂。这些乙烯加成聚合物具有一些取代基的组合，包括在低pH下提供阳离子性质的氨基取代基、疏水取代基、疏水改性的聚氧烷基取代基和亲水性的聚氧烷基取代基。这些聚合物在酸性水性组合物中提供了出乎意料的有益流变特性，并且与阳离子材料兼容。此外，本发明还涉及在添加酸性物质后加入碱性物质以降低组合物的pH值，而不会对组合物的粘度产生负面影响。这些多用途聚合物在个人护理、健康护理、家庭护理、机构和工业护理以及工业应用的各种产品中非常有用。
• COSMETIC COMPOSITION FOR USE ON HAIR AND CONTAINING AN ACYL BASIC AMINO ACID DERIVATIVE
  申请人：AJINOMOTO CO., INC.

  公开号：US20170281494A1

  公开（公告）日：2017-10-05

  The present invention provides a composition containing component (A): a compound represented by the formula (1) wherein each symbol is as described in the DESCRIPTION, or a salt thereof and component (B): a cationic surfactant, which is superior in the usability during rinsing, which makes the hair surface after treatment smooth and free of dry feeling, provides a uniform touch feeling from the root of the hair to the tip thereof, and can be utilized as an aqueous cosmetic.

  本发明提供一种组合物，包含成分（A）：一种由式（1）表示的化合物，其中每个符号如描述中所述，或其盐，以及成分（B）：一种阳离子表面活性剂，具有良好的冲洗使用性能，使得经过处理后的头发表面光滑且没有干燥感，从头发根部到末端提供均匀的触感，可以用作水基化妆品。
• [EN] HAIR CONDITIONING COMPOSITION COMPRISING CARBOXYLIC ACID/CARBOXYLATE COPOLYMER, SILICONE COMPOUND, AND HIGH MELTING POINT COMPOUND<br/>[FR] COMPOSITION POUR LE CONDITIONNEMENT DES CHEVEUX COMPRENANT UN COPOLYMERE ACIDE CARBOXYLIQUE/CARBOXYLATE, UN COMPOSE DE SILICONE ET UN COMPOSE AYANT UN POINT DE FUSION ELEVE
  申请人：PROCTER & GAMBLE

  公开号：WO2000006098A1

  公开（公告）日：2000-02-10

  Disclosed is a hair conditioning composition comprising: (1) a carboxylic acid/carboxylate copolymer; (2) a silicone compound; (3) a high melting point compound; and (4) an aqueous carrier.

  公开的一种头发护理组合物包括：（1）羧酸/羧酸盐共聚物；（2）硅氧烷化合物；（3）高熔点化合物；和（4）水性载体。