Ethyl 2-(4-chlorophenyl)morpholine-4-carboxylate | 127635-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: Ethyl 2-(4-chlorophenyl)morpholine-4-carboxylate
• CAS: 127635-02-3
• 化学式: C₁₃H₁₆ClNO₃
• mdl: MFCD16905773
• 分子量: 269.728
• InChiKey: JLCRVKSMDPOHHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethyl 2-(4-chlorophenyl)morpholine-4-carboxylate 在 盐酸 、 硫酸 作用下， 生成 2-(4-Chlorophenyl)morpholine hydrochloride
  参考文献：
  名称：

  Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines

  摘要：

  The synthesis of nine original morpholine derivatives, i.e.2-aryl-4-(3-arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and H-1-NMR, and some C-13-NMR. Acute toxicity studies of the compounds of them by were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was studied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria preparations.

  DOI：

  10.1002/(sici)1521-4184(199811)331:11<342::aid-ardp342>3.0.co;2-6
• 作为产物：
  描述：

  氯甲酸乙酯 、 2-(4-Chlorophenyl)-4-methylmorpholine 以 苯 为溶剂， 反应 2.0h， 生成 Ethyl 2-(4-chlorophenyl)morpholine-4-carboxylate
  参考文献：
  名称：

  Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines

  摘要：

  The synthesis of nine original morpholine derivatives, i.e.2-aryl-4-(3-arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and H-1-NMR, and some C-13-NMR. Acute toxicity studies of the compounds of them by were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was studied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria preparations.

  DOI：

  10.1002/(sici)1521-4184(199811)331:11<342::aid-ardp342>3.0.co;2-6

文献信息

• AVRAMOVA, P.;JORDANOVA, K.;GAGAUZOV, J., FARMATSIYA, 39,(1989) N, S. 1-5
  作者：AVRAMOVA, P.、JORDANOVA, K.、GAGAUZOV, J.

  DOI：——

  日期：——