(E)-2-hydroxy-N'-(1-phenylethylidene)benzohydrazide | 1206732-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-hydroxy-N'-(1-phenylethylidene)benzohydrazide
• 英文别名: 2-hydroxy-N'-[(1E)-1-phenylethylidene]benzohydrazide；2-hydroxy-N-[(E)-1-phenylethylideneamino]benzamide
• CAS: 1206732-60-6
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: WFXWQJZQAHFAQN-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  水杨酰肼 、 苯乙炔 在 gold(I) ethyldiphenylphosphine complex immobilized on MCM-41 mesoporous silica 作用下， 以 氯苯 为溶剂， 反应 2.0h， 以98%的产率得到(E)-2-hydroxy-N'-(1-phenylethylidene)benzohydrazide
  参考文献：
  名称：

  可回收的金（I）催化末端炔烃加氢生成酮基-N-酰基腙

  摘要：

  使用 MCM-41 固定的二苯基膦金 (I) 配合物 [Ph 2 P-MCM-41 ，在 60 °C 的氯苯中，开发了一种简便高效的非均相金 (I) 催化的末端炔烃与多种酰肼的加氢反应。-AuNTf 2 ] 作为催化剂，为合成多种取代的酮基-N-酰基腙提供了一种新颖实用的方法，产率从良好到优异。这种异质化的金 (I) 催化剂也很容易通过过滤反应混合物来回收，并且可以回收多达八次，而没有任何明显的催化效率损失。

  DOI：

  10.1016/j.jorganchem.2022.122411

文献信息

• Fast Synthesis of <i>N</i>-Acylhydrazones Employing a Microwave Assisted Neat Protocol
  作者：Marta M. Andrade、Maria Teresa Barros

  DOI：10.1021/cc9001444

  日期：2010.3.8

  A variety of N-acylhydrazones were synthesized Under microwave irradiation within 2.5-10 min, starting from benzo, salicyloyl, and isonicotinic hydrazides. The protocol developed employs microwave irradiation in the absence of solvents and catalysts, leading to high yields. The results are reproducible in a 500 mg to 5 g scale.
• Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes
  作者：Dmitry P. Zimin、Dmitry V. Dar’in、Valentin A. Rassadin、Vadim Yu. Kukushkin

  DOI：10.1021/acs.orglett.8b02019

  日期：2018.8.17

  Facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides (RCONHNH2)-C-2 (R = Alk or Ar; including those with an additional nudeophilic moiety) in the presence of Ph3PAuNTf2 (6 mol %) leading to a wide range of substituted keto-N-acylhydrazones (18 examples) in excellent to good yields (99-66%) is reported. This novel metal-catalyzed coupling proceeds under mild conditions (chlorobenzene, 60 degrees C), exhibits high functional group tolerance, and is insensitive to the electronic and steric effects of the substituents in the reactants.
• Compounds for Targeting Cancer Stem Cells
  申请人：The General Hospital Corporation

  公开号：US20210238140A1

  公开（公告）日：2021-08-05

  This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided.