N-(tert-butyldimethylsilyl)aminomorpholine | 1413917-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(tert-butyldimethylsilyl)aminomorpholine
• CAS: 1413917-28-8
• 化学式: C₁₀H₂₄N₂OSi
• 分子量: 216.399
• InChiKey: JSWKETKEEVBVTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.5
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-(tert-butyldimethylsilyl)aminomorpholine 、 对硝基苯甲醛 以 氘代氯仿 为溶剂， 反应 192.0h， 以8%的产率得到N-morpholino-1-(4-nitrophenyl)methanimine
  参考文献：
  名称：

  N-Silyloxaziridines: Synthesis and Use for Electrophilic Amination

  摘要：

  N-Silyloxaziridines were synthesized for the first time. Their tert-butyldiphenylsilyl (TBDPS) derivatives were stable reagents that were prepared on a multigram scale in three steps and in 44% overall yield from the corresponding benzylamines. They were mild electrophilic aminating reagents that reacted at room temperature with diversely substituted primary and secondary amines to produce N-monoalkyl or N,N-dialkyl benzaldehyde hydrazones in 44-87% yield.

  DOI：

  10.1021/jo302182t
• 作为产物：
  描述：

  4-氨基吗啉 、 叔丁基二甲基氯硅烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 乙醚 为溶剂， 反应 48.0h， 以66%的产率得到N-(tert-butyldimethylsilyl)aminomorpholine
  参考文献：
  名称：

  N-Silyloxaziridines: Synthesis and Use for Electrophilic Amination

  摘要：

  N-Silyloxaziridines were synthesized for the first time. Their tert-butyldiphenylsilyl (TBDPS) derivatives were stable reagents that were prepared on a multigram scale in three steps and in 44% overall yield from the corresponding benzylamines. They were mild electrophilic aminating reagents that reacted at room temperature with diversely substituted primary and secondary amines to produce N-monoalkyl or N,N-dialkyl benzaldehyde hydrazones in 44-87% yield.

  DOI：

  10.1021/jo302182t