5-(2-phthalimidoethoxy)-isophthalic acid | 198700-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-phthalimidoethoxy)-isophthalic acid
• CAS: 198700-46-8
• 化学式: C₁₈H₁₃NO₇
• 分子量: 355.304
• InChiKey: DVLOSPDVORPGJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.76
• 重原子数：
  26.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  121.21
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  5-(2-phthalimidoethoxy)-isophthalic acid 、 dimethyl 5-(2-aminoethoxy)benzene-1,3-dicarboxylate 在 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以59%的产率得到α-[5-(2-phthalimidoethoxy)-(3,5-biscarbonylphenyl)]-ω-(tetra-oxymethyl)-poly[iminoethoxy-(3,5-bis(carbonylphenyl))]
  参考文献：
  名称：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid

  摘要：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid have been synthesized up to generation 4 following the convergent approach. This involved a repetitive reaction of 5-(2-t-butoxycarbamylethoxy)-isophthalic acid with the two fold excess of 5-(2-aminoethoxy-hydrochloride)-isophthalic acid dimethyl ester and its analogs of higher generation, respectively, using activation and protection methods from the peptide chemistry. The products were characterized via elemental analysis, different spectroscopic methods, gel permeation chromatograpy, and differential scanning calorimetry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00978-2
• 作为产物：
  描述：

  5-(2-phthalimidoethoxy)-isophthalic acid dimethyl ester 在 盐酸 、 溶剂黄146 作用下， 反应 3.0h， 以60%的产率得到5-(2-phthalimidoethoxy)-isophthalic acid
  参考文献：
  名称：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid

  摘要：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid have been synthesized up to generation 4 following the convergent approach. This involved a repetitive reaction of 5-(2-t-butoxycarbamylethoxy)-isophthalic acid with the two fold excess of 5-(2-aminoethoxy-hydrochloride)-isophthalic acid dimethyl ester and its analogs of higher generation, respectively, using activation and protection methods from the peptide chemistry. The products were characterized via elemental analysis, different spectroscopic methods, gel permeation chromatograpy, and differential scanning calorimetry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00978-2