1-Morpholino-2-(tributylstannyl)ethin | 102265-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1-Morpholino-2-(tributylstannyl)ethin
• 英文别名: N-(2-Tributylstannylethinyl)morpholin；N-(Tributylstannylethinyl)morpholin；4-tributylstannanylethynyl-morpholine；tributyl(2-morpholin-4-ylethynyl)stannane
• CAS: 102265-89-4
• 化学式: C₁₈H₃₅NOSn
• 分子量: 400.192
• InChiKey: FRCSTQBKEPXWPO-UHFFFAOYSA-N

物化性质

• 沸点：
  120-121 °C(Press: 0.01 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  4.67
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Morpholino-2-(tributylstannyl)ethin 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 生成 3,3,3-Triphenylpropionsaeure-morpholid
  参考文献：
  名称：

  Himbert, Gerhard; Giesa, Reiner, Liebigs Annalen der Chemie, 1986, # 2, p. 292 - 298

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1,2-Trichloro-2-morpholinoethen 、 三丁基氯化锡 、 正丁基锂 以48%的产率得到
  参考文献：
  名称：

  HIMBERT, G.;GIESA, R., LIEBIGS ANN. CHEM., 1986, N 2, 292-298

  摘要：

  DOI：

文献信息

• [EN] TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE TRIAZOLE EN TANT QU'ANTAGONISTES DES RECEPTEURS DE LA TACHYKININE
  申请人：LILLY CO ELI

  公开号：WO2003091226A1

  公开（公告）日：2003-11-06

  This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents indpendently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

  这个应用涉及到Formula (I)的化合物或其药用盐，以及其药物组合物，以及其作为NK-1亚型的催吐肽受体抑制剂的用途，以及其制备方法和中间体。其中：D是C1-C3烷二基；R1是苯基，可以选择地用来自卤素、C1-C4烷基、C1-C4烷氧基、氰基、二氟甲基、三氟甲基和三氟甲氧基的一到三个取代基中的任意一个取代基取代；R4是从以下组成的基团中选择的基团：(IA)、(IB)、(IC)、(ID)、(IE)、(IF)、(IG)、(IH)
• Triazole derivatives as tachykinin receptor antagonists
  申请人：Amegadzie Kudzovi Albert

  公开号：US20050239786A1

  公开（公告）日：2005-10-27

  This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C 1 -C 3 alkane-diyl; R 1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R 4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

  本申请涉及化合物I式或其药学上可接受的盐，其药物组合物以及其作为tachykinin受体NK-1亚型的抑制剂的用途，以及其制备过程和中间体。其中：D是C1-C3烷基二亚基；R1是苯基，可选地取代为一个至三个取代基，独立地选自卤素，C1-C4烷基，C1-C4烷氧基，氰基，二氟甲基，三氟甲基和三氟甲氧基的群；R4是从群 consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)中选择的基团。
• Synthese von gestapelten `Push-Pull'-Acetylenen
  作者：Daniel Berger、Patrick Wilhelm、Markus Neuenschwander

  DOI：10.1002/(sici)1522-2675(19990310)82:3<326::aid-hlca326>3.0.co;2-l

  日期：1999.3.10

  In view of possible solid-state polymerizations of crystalline stacked 'push-pull'-acetylenes 1. a series of compounds 1 has been synthesized (Scheme 3), and the results of,X-ray analyses of 'push-pull'-acetylenes Id,e,f are discussed. Of these three compounds, methyl 2-morpholinoacetylene carboxylate (Id) is by far the best candidate giving crystals with nicely stacked molecules (Fig. 3). Even in this case, however, stacking parameters d= 4,12 Angstrom and alpha = 31,6 degrees are too large for allowing solid-state polymerizations.
• Himbert, Gerhard; Kosack, Steffen, Chemische Berichte, 1988, vol. 121, p. 2163 - 2170
  作者：Himbert, Gerhard、Kosack, Steffen

  DOI：——

  日期：——
• HIMBERT, GERHARD;KOSACK, STEFFEN, CHEM. BER., 121,(1988) N2, C. 2163-2170
  作者：HIMBERT, GERHARD、KOSACK, STEFFEN

  DOI：——

  日期：——