glycine octylamide | 97515-33-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glycine octylamide
• 英文别名: glycine octyl amide；Acetamide, 2-amino-N-octyl-；2-amino-N-octylacetamide
• CAS: 97515-33-8
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.297
• InChiKey: FJHUXLJRZDOBRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  glycine octylamide 在 4-二甲氨基吡啶 、 palladium on activated charcoal 、 氢气 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 2-amino-3-(1H-imidazol-5-yl)-N-[2-(octylamino)-2-oxoethyl]propanamide
  参考文献：
  名称：

  Metalloporphyrin receptors for histidine-containing peptides

  摘要：

  Two new ditopic metalloporphyrin receptors constructed by combining metalloporphyrin with crown ethers have been prepared and characterized. H-1 NMR and MS spectra confirmed the complexation of receptor with peptide driven by coordination interaction and hydrogen bonding. UV/vis experiments revealed that the receptors exhibited high binding affinity to histidine-containing peptides. These receptors could differentiate short peptides of C-terminal histidine and N-terminal histidine and formed the most stable complexes with tripeptide. (C) 2014 Hui Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.03.034
• 作为产物：
  描述：

  Z-glycine octylamide 在 5%-palladium/activated carbon 氢气 作用下， 以 甲醇 为溶剂， 反应 120.0h， 以100%的产率得到glycine octylamide
  参考文献：
  名称：

  Gelling agents

  摘要：

  该发明涉及一种新型凝胶剂类别，一种制备该剂的方法，使用该剂来制备凝胶，以及由此获得的凝胶。根据该发明，一种凝胶剂或增稠剂包括通过酰胺或脲键与三个氨基酸酯或酰胺基团功能化的刚性核心。它可以用于凝胶或增稠许多溶剂。

  公开号：

  EP1364941A1

文献信息

• Combinatorial Evolution of Fast-Conducting Highly Selective K⁺-Channels via Modularly Tunable Directional Assembly of Crown Ethers
  作者：Changliang Ren、Jie Shen、Huaqiang Zeng

  DOI：10.1021/jacs.7b04335

  日期：2017.9.13

  of highly efficient K+-selective channels. In our strategy, a highly robust supramolecular H-bonded 1D ensemble was used to order the appended crown ethers in such a way that they roughly stack on top of each other to form a channel for facilitated ion transport across the membrane. Among 15 channels that all prefer K+ over Na+ ions, channel molecule 5F8 shows the most pronounced optimum for K+ while

  我们在这里描述了用于高效K +选择通道的构建和组合优化的模块化可调分子策略。在我们的策略中，使用高度健壮的超分子H键合1D集成体来订购附加的冠醚，以使它们彼此大致堆叠以形成通道，以促进离子跨膜传输。在15个都比Na +离子更喜欢K +的通道中，通道分子5F8显示了最明显的K +最佳值，同时不利于所有其他生物学上重要的阳离子（例如Na +，Ca 2+和Mg 2+）。用K + / Na+对K +离子的选择性为9.8，EC 50值为6.2μM，5F8显然是过去几十年来开发的最佳合成钾通道之一。
• C3-Symmetric, amino acid based organogelators and thickeners: a systematic study of structure–property relations
  作者：Maaike de Loos、Jan H. van Esch、Richard M. Kellogg、Ben L. Feringa

  DOI：10.1016/j.tet.2007.02.066

  日期：2007.7

  A class of C-3-symmetric amino acid based organogelators and thickeners featuring a rigid core have been developed. Structural variation yielded a number of compounds, the aggregation behaviour and resulting aggregates and gels of which were studied by FTIR spectroscopy, dropping ball measurements, differential scanning calorimetry and transmission electron microscopy. These studies showed that the nature of the core unit, the type of hydrogen-bonding units and the applied amino acids have a strong influence on the interactions, resulting in large differences in aggregation properties, thermal stability and morphology between the various compounds. The results provide a basis for a better understanding of the relation between aggregate/gel properties and molecular structure. The structural variation available for these compounds allows fine-tuning of the gelators with respect to aggregation behaviour and gel properties. (c) 2007 Published by Elsevier Ltd.
• The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
  作者：Helen F. Boyd、Beverley Hammond、Deirdre M.B. Hickey、Robert J. Ife、Colin A. Leach、V.Ann Lewis、Colin H. Macphee、Kevin J. Milliner、Ivan L. Pinto、Stephen A. Smith、Ian G. Stansfield、Colin J. Theobald、Caroline M. Whittaker

  DOI：10.1016/s0960-894x(01)00038-5

  日期：2001.3

  Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A(2), has given inhibitors of nanomolar potency and improved physicochemical properties. Compound 23 was identified as a potent, highly water soluble, CNS penetrant inhibitor suitable for intravenous administration. (C) 2001 Elsevier Science Ltd. All rights reserved.
• GELLING AGENTS
  申请人：Applied NanoSystems B.V.

  公开号：EP1506168B1

  公开（公告）日：2008-04-30
• Semi-Synthetic GLP-1 Peptide-FC Fusion Constructs, Methods and Uses
  申请人：Heavner George

  公开号：US20090181037A1

  公开（公告）日：2009-07-16

  The invention relates to semi-synthetic biologic molecules which are conjugates of GLP-1 peptides and human multimeric proteins or protein fragments, such as an antibody Fc joined by a non-peptidyl bond. The constructs demonstrate biological activity and are useful making therapeutic compositions and therapeutic formulations for use in treating diseases characterized by lack of glycemic control.