22-[2-[2-[2-[Bis(2-ethoxy-2-oxoethyl)amino]ethoxy]ethoxy]ethylamino]-22-oxodocosa-10,12-diynoic acid | 287401-60-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 22-[2-[2-[2-[Bis(2-ethoxy-2-oxoethyl)amino]ethoxy]ethoxy]ethylamino]-22-oxodocosa-10,12-diynoic acid
• CAS: 287401-60-9
• 化学式: C₃₆H₆₀N₂O₉
• 分子量: 664.88
• InChiKey: YBIGYOZFHCBWTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  47
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  22-[2-[2-[2-[Bis(2-ethoxy-2-oxoethyl)amino]ethoxy]ethoxy]ethylamino]-22-oxodocosa-10,12-diynoic acid 在 lithium hydroxide 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 反应 32.0h， 生成 [9-[2-[2-[[22-[2-[2-[2-[Bis(carboxymethyl)amino]ethoxy]ethoxy]ethylamino]-22-oxodocosa-10,12-diynoyl]amino]ethylcarbamoyl]phenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazanium
  参考文献：
  名称：

  Synthesis and Fluorescence Properties of New Fluorescent, Polymerizable, Metal-Chelating Lipids

  摘要：

  Liposomes incorporating fluorescent, metal-chelating lipids find applications in molecular recognition of peptides, 2D protein recystallization, protein targeting, and biological sensing. It would be advantageous to combine the usefulness of polymerizable, metal-chelating lipids and fluorescent lipids. Herein, we report the synthesis and fluorescence properties of several fluorescent, polymerizable, metal-chelating lipids. They have been successfully incorporated into liposomes and then polymerized. These lipids can be used as membrane probes to study the polymerizable liposomes in the unpolymerized state and to investigate lipid redistribution during polymerization. In addition, if a luminescent metal ion (e.g., Eu3+, Tb3+, etc.) is used to complex the headgroup, the lipids can probe the membrane interior and exterior simultaneously.

  DOI：

  10.1021/jo991836r
• 作为产物：
  描述：

  10,12-二十二碳二炔二酸 、 Ethyl 2-[2-[2-(2-aminoethoxy)ethoxy]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以61%的产率得到22-[2-[2-[2-[Bis(2-ethoxy-2-oxoethyl)amino]ethoxy]ethoxy]ethylamino]-22-oxodocosa-10,12-diynoic acid
  参考文献：
  名称：

  Synthesis and Fluorescence Properties of New Fluorescent, Polymerizable, Metal-Chelating Lipids

  摘要：

  Liposomes incorporating fluorescent, metal-chelating lipids find applications in molecular recognition of peptides, 2D protein recystallization, protein targeting, and biological sensing. It would be advantageous to combine the usefulness of polymerizable, metal-chelating lipids and fluorescent lipids. Herein, we report the synthesis and fluorescence properties of several fluorescent, polymerizable, metal-chelating lipids. They have been successfully incorporated into liposomes and then polymerized. These lipids can be used as membrane probes to study the polymerizable liposomes in the unpolymerized state and to investigate lipid redistribution during polymerization. In addition, if a luminescent metal ion (e.g., Eu3+, Tb3+, etc.) is used to complex the headgroup, the lipids can probe the membrane interior and exterior simultaneously.

  DOI：

  10.1021/jo991836r