(1RS,3R)-7-chloro-3-methyl-1-(3-methyl-4-nitrophenyl)-isochromane | 943964-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1RS,3R)-7-chloro-3-methyl-1-(3-methyl-4-nitrophenyl)-isochromane
• 英文别名: (3R)-7-chloro-3-methyl-1-(3-methyl-4-nitrophenyl)-3,4-dihydro-1H-isochromene
• CAS: 943964-13-4
• 化学式: C₁₇H₁₆ClNO₃
• 分子量: 317.772
• InChiKey: OFULEDGFFKMJNL-VCQTYVLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1RS,3R)-7-chloro-3-methyl-1-(3-methyl-4-nitrophenyl)-isochromane 在 sodium hydroxide 、 氧气 、 盐酸 作用下， 以 水 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 (1RS,3R)-7-chloro-3-methyl-1-(3-methyl-4-nitrophenyl)-isochroman-1-ol
  参考文献：
  名称：

  WO2007/77469

  摘要：

  公开号：
• 作为产物：
  描述：

  (-)-1-(4-chloro-phenyl)-2-propanol 、 3-甲基-4-硝基苯甲醛 在 盐酸 、 zinc(II) chloride 作用下， 以 苯 为溶剂， 反应 6.5h， 以21.5%的产率得到(1RS,3R)-7-chloro-3-methyl-1-(3-methyl-4-nitrophenyl)-isochromane
  参考文献：
  名称：

  WO2007/77469

  摘要：

  公开号：

文献信息

• OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS
  申请人：Ling Istvan

  公开号：US20090233913A1

  公开（公告）日：2009-09-17

  The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.

  本发明涉及高对映纯度的二氢-2,3-苯并二氮平化合物，其通式为(I)，其中在二氢-2,3-苯并二氮平化合物的4位含有不对称中心，以及其制备方法和用作中间体。这些化合物具有抗惊厥、肌肉松弛和神经保护作用，因为它们具有非竞争性AMPA拮抗作用。
• Method of using NF3 for removing surface deposits from the interior of chemical vapor deposition chambers
  申请人：Sawin H. Herbert

  公开号：US20070107750A1

  公开（公告）日：2007-05-17

  The present invention relates to a remote plasma cleaning method for removing surface deposits from a surface, such as the interior of a depositions chamber that is used in fabricating electronic devices. The process involves activating a gas stream comprising an oxygen source, NF 3 , and a fluorocarbon and contacting the activated gas mixture with surface deposits to remove the surface deposits.
• Method for removing surface deposits and passivating interior surfaces of the interior of a chemical vapor deposition reactor
  申请人：Sawin Herbert H.

  公开号：US20090047447A1

  公开（公告）日：2009-02-19

  The present invention relates to plasma cleaning methods for removing surface deposits from a surface, such as the interior of a depositions chamber that is used in fabricating electronic devices. The present invention also provides gas mixtures and activated gas mixtures which provide superior performance in removing deposits from a surface. The methods involve activating a gas mixture comprising a carbon or sulfur source, NF 3 , and optionally, an oxygen source to form an activated gas, and contacting the activated gas mixture with surface deposits to remove the surface deposits wherein the activated gas mixture acts to passivate the interior surfaces of the apparatus to reduce the rate of surface recombination of gas phase species.
• [EN] OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS<br/>[FR] ISOMERES OPTIQUES DE DIHYDRO-2,3-BENZODIAZEPINES ET LEUR SYNTHESE STEREOSELECTIVE
  申请人：EGIS GYOGYSZERGYAR NYRT

  公开号：WO2007077469A1

  公开（公告）日：2007-07-12

  [EN] The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.
  [FR] La présente invention concerne des composés de dihydro-2,3-benzodiazépine de pureté énantiomérique élevée selon la formule générale (I), qui contiennent un centre asymétrique à la position 4 du composé de dihydro-2,3-benzodiazépine, et leur préparation ainsi que les intermédiaires utilisés. Ces composés ont un effet myorelaxant anticonvulsif neuroprotecteur en raison de leurs propriétés antagonistes d'AMPA non compétitives.