5-(2-methoxyethoxy)-2-methylaniline | 861008-27-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(2-methoxyethoxy)-2-methylaniline
• 英文别名: 5-(2-Methoxy-aethoxy)-2-methyl-anilin
• CAS: 861008-27-7
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: ZQXHLFFOROUKTJ-UHFFFAOYSA-N

物化性质

• 沸点：
  172 °C(Press: 9 Torr)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(2-methoxyethoxy)-2-methylaniline 在 甲醇 、 N-溴代丁二酰亚胺(NBS) 、 18-冠醚-6 、 potassium acetate 、 potassium carbonate 作用下， 以 甲苯 、 乙腈 为溶剂， 生成 5-bromo-6-(2-methoxyethoxy)-1H-indazole
  参考文献：
  名称：

  WO2020165062A5

  摘要：

  公开号：

  WO2020165062A5
• 作为产物：
  描述：

  1-methoxy-2-(4-methyl-3-nitro-phenoxy)-ethane 生成 5-(2-methoxyethoxy)-2-methylaniline
  参考文献：
  名称：

  Indigoid vat dyestuffs

  摘要：

  公开号：

  US02080862A1

文献信息

• [EN] PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT<br/>[FR] DÉRIVÉS DE PYRAZOLOPYRIMIDINE, LEUR PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE POUR UTILISATION DANS LA PRÉVENTION OU LE TRAITEMENT DU CANCER, D'UNE MALADIE AUTO-IMMUNE ET D'UNE MALADIE DU CERVEAU CONTENANT CEUX-CI EN TANT QUE PRINCIPE ACTIF
  申请人：KOREA RES INST CHEMICAL TECH

  公开号：WO2018208132A1

  公开（公告）日：2018-11-15

  The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

  本发明涉及一种吡唑并嘧啶衍生物，其制备方法以及包含该衍生物作为活性成分的药物组合物，用于预防或治疗癌症、自身免疫病和脑病。本发明的吡唑并嘧啶衍生物展现出卓越的布鲁顿酪氨酸激酶抑制活性，因此可以有效地用作预防或治疗癌症、自身免疫病和帕金森病的药物组合物。
• Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
  申请人：Korea Research Institute of Chemical Technology

  公开号：US11084824B2

  公开（公告）日：2021-08-10

  The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

  本发明涉及一种吡唑嘧啶衍生物、其制备方法以及以其为活性成分的药物组合物，用于预防或治疗癌症、自身免疫性疾病和脑部疾病。本发明的吡唑嘧啶衍生物具有优异的布鲁顿酪氨酸激酶抑制活性，因此可以有效地用作预防或治疗癌症、自身免疫性疾病和帕金森病的药物组合物。
• PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Korea Research Institute of Chemical Technology

  公开号：US20200199129A1

  公开（公告）日：2020-06-25

  The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.
• INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER
  申请人：Merck Patent GmbH

  公开号：US20220127254A1

  公开（公告）日：2022-04-28

  Compounds of the formula I are provided. These compounds can inhibit c-Kit kinase and can be employed for the treatment of cancer.
• [EN] INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER<br/>[FR] DÉRIVÉS D'INDAZOLYL-ISOXAZOLE POUR LE TRAITEMENT DE MALADIES TELLES QUE LE CANCER
  申请人：MERCK PATENT GMBH

  公开号：WO2020165062A1

  公开（公告）日：2020-08-20

  Compounds of the formula (I) in which R1, R2, X, Y and Z have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.