4,5-二甲氧基-2-硝基-苯酚 | 7158-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,5-二甲氧基-2-硝基-苯酚
• 英文名称: 4,5-Dimethoxy-2-nitro-phenol
• 英文别名: 5-Nitro-4-hydroxy-1.2-dimethoxy-benzol；4,5-Dimethoxy-2-nitrophenol
• CAS: 7158-91-0
• 化学式: C₈H₉NO₅
• 分子量: 199.163
• InChiKey: KBEJHHWQKHGDNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,5-二甲氧基-2-硝基-苯酚 在 盐酸 、 tin 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 N-(2-Benzyloxy-4,5-dimethoxy-phenyl)-N-(2-diethylamino-ethyl)-N',N'-diethyl-ethane-1,2-diamine
  参考文献：
  名称：

  抗疟疾2-溴-N，N-双（二乙基氨基乙基）-4,5-二甲氧基苯胺的类似物。2位置变化。

  摘要：

  DOI：

  10.1021/jm00300a021
• 作为产物：
  描述：

  3,4-二甲氧基苯酚 在 nitronium tetrafluoborate 作用下， 以 乙二醇二甲醚 为溶剂， 以65%的产率得到4,5-二甲氧基-2-硝基-苯酚
  参考文献：
  名称：

  The nitration of electron-rich aromatics

  摘要：

  The successful mononitration of a variety of electron-rich aromatic substrates is reported, employing either nitronium tetrafluoroborate or "claycop" as the nitrating agent. Dinitration of four of the substrates was achieved when employing nitronium tetrafluoroborate. Several of the products have previously been prepared only by indirect methods. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00418-9

文献信息

• Palladium-catalyzed C–O bond formation: direct synthesis of phenols and aryl/alkyl ethers from activated aryl halides
  作者：Guoshu Chen、Albert S.C. Chan、Fuk Yee Kwong

  DOI：10.1016/j.tetlet.2006.11.036

  日期：2007.1

  palladium-catalyzed carbon–oxygen bond formation is reported. The palladium-tri-tert-butylphosphine complex was found to be effective in converting haloarenes to corresponding substituted phenols. This methodology offers a direct transformation of aryl halides to phenols, as well as the straightforward application to generate a wide variety of diaryl or alkyl/aryl ethers.

  据报道，形成了一种简单有效的钯催化的碳氧键。钯-三-叔丁基膦配合物被发现是有效的卤代芳烃转化成相应的取代的酚。这种方法可以将芳基卤化物直接转化为苯酚，并且可以直接用于生成各种二芳基或烷基/芳基醚。
• Topical compositions comprising protected functional thiols
  申请人：——

  公开号：US20020012639A1

  公开（公告）日：2002-01-31

  This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr) m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.

  这项发明涉及一种用于处理氨基酸基底的局部组合物，包括具有以下结构的受保护硫化合物R—(S—Pr)m，其中R是功能基团，S是硫，Pr是一个杂环保护基团，m是介于1和100之间的整数。该发明还涉及包含该受保护硫化合物和一个活化机制的系统。本发明的受保护硫化合物可用于头发护理组合物、纺织品护理组合物、化妆品组合物、口腔护理组合物、皮肤护理、指甲护理、洗涤护理、痤疮护理和动物护理组合物。本发明的优选实施例提供了一种改性紫外线吸收剂和一种改性抗氧化剂，以及制备它们和包含它们的组合物的方法。
• PREPARATION OF 3,4-METHYLENEDIOXY- AND 3,4-DIMETHOXY-6-AMINOPHENOL
  作者：D. G. Orphanos、A. Taurins

  DOI：10.1139/v66-283

  日期：1966.8.1

  not available

  不可用
• Isolation and Synthesis of an α-Malamic Acid Derivative from <i>Justicia ghiesbreghtiana</i>
  作者：Lotfy D. Ismail、Peter Lorenz、Frank R. Stermitz

  DOI：10.1021/np9801662

  日期：1998.9.1

  ghiesbreghtiana yielded N-(2-hydroxy-4,5-dimethoxyphenyl)-(S)-alpha-malamic acid, 1. Incomplete spectral analysis yielded a hypothetical structure, which was then proven by total synthesis. Coupling of the trifluoroacetate of malic anhydride (trifluoroacetoxysuccinic anhydride) with an arylamine provided the key to regiospecific preparation of the alpha- rather than beta-malamic acids.

  Justicia ghiesbreghtiana的叶子的极性提取物产生N-（2-羟基-4,5-二甲氧基苯基）-（S）-α-苹果酸1。不完全的光谱分析产生了一种假设的结构，然后通过全合成对其进行了证明。苹果酸酐的三氟乙酸盐（三氟乙酰氧基琥珀酸酐）与芳基胺的偶联为α-苹果酸而不是β-苹果酸的区域特异性制备提供了关键。
• Diaminotriazoles useful as inhibitors of protein kinases
  申请人：——

  公开号：US20040214817A1

  公开（公告）日：2004-10-28

  The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及蛋白激酶抑制剂。本发明还提供了包含本发明化合物的制药组合物以及使用该组合物治疗各种疾病的方法。