methyl (6R,8aR)-5-oxospiro[2,3,7,8-tetrahydro-1H-indolizine-6,2'-pyrrolidine]-8a-carboxylate | 884867-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (6R,8aR)-5-oxospiro[2,3,7,8-tetrahydro-1H-indolizine-6,2'-pyrrolidine]-8a-carboxylate
• CAS: 884867-03-2
• 化学式: C₁₃H₂₀N₂O₃
• 分子量: 252.313
• InChiKey: RMVMVKMAXDFSBN-CHWSQXEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.44
• 重原子数：
  18.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  58.64
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  methyl (6R,8aR)-5-oxospiro[2,3,7,8-tetrahydro-1H-indolizine-6,2'-pyrrolidine]-8a-carboxylate 在 N-甲基吗啉 作用下， 以 二氯甲烷 为溶剂， 生成 (2R,2'R)-2,2'-ethano-cyclo(Pro-Pro)
  参考文献：
  名称：

  Concerted Synthesis of a Spirobicyclic Type-VI β-Turn Mimic of Pro-Pro-Pro-NH₂

  摘要：

  A highly concerted strategy for the synthesis of symmetrical type-VI beta-turn mimics was formulated. A proof of concept is presented in the synthesis of a spirobicyclic peptidomimetic of Pro-Pro-Pro-NH2, compound 6. The formation of an unusual adduct that was encountered in the process also is reported. This approach is potentially general for type-VI beta-turn mimics where the i + 1 and i + 2 residues are identical.

  DOI：

  10.1021/ol0600335
• 作为产物：
  描述：

  (2R,2'R)-2,2'-ethano-cyclo(Pro-Pro) 在 盐酸 作用下， 以 甲苯 为溶剂， 反应 8.0h， 生成 methyl (6R,8aR)-5-oxospiro[2,3,7,8-tetrahydro-1H-indolizine-6,2'-pyrrolidine]-8a-carboxylate
  参考文献：
  名称：

  Concerted Synthesis of a Spirobicyclic Type-VI β-Turn Mimic of Pro-Pro-Pro-NH₂

  摘要：

  A highly concerted strategy for the synthesis of symmetrical type-VI beta-turn mimics was formulated. A proof of concept is presented in the synthesis of a spirobicyclic peptidomimetic of Pro-Pro-Pro-NH2, compound 6. The formation of an unusual adduct that was encountered in the process also is reported. This approach is potentially general for type-VI beta-turn mimics where the i + 1 and i + 2 residues are identical.

  DOI：

  10.1021/ol0600335