7-oxo-2-phenyl-6,7-dihydro-5H-<1>pyridine | 247185-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7-oxo-2-phenyl-6,7-dihydro-5H-<1>pyridine
• 英文别名: 2-phenyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one；2-Phenyl-5,6-dihydrocyclopenta[b]pyridin-7-one；2-phenyl-5,6-dihydrocyclopenta[b]pyridin-7-one
• CAS: 247185-54-2
• 化学式: C₁₄H₁₁NO
• 分子量: 209.247
• InChiKey: GBUIGUYEDMYGLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-oxo-2-phenyl-6,7-dihydro-5H-<1>pyridine 在 lithium aluminium tetrahydride 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 27.5h， 生成 (+/-)-6,6-diethyl-7-<formamidyl>oxy-2-phenyl-6,7-dihydro-5H-<1>pyridine
  参考文献：
  名称：

  Synthesis of chiral plane-extended pyridyl alcohols for the enantioselective addition of diethylzinc to aldehydes

  摘要：

  Enantiomerically pure pyridyl alcohols, 1 and 2, were prepared from readily available racemic pyridyl alcohol 3 and applied to the enantioselective addition of diethylzinc to aldehydes resulting in moderately high enantiomeric excess (90%) in the case of benzaldehyde. In this study the first example of an alteration in the configuration of the product upon change of a non-chiral and non-coordinating part of the catalyst was observed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00247-5
• 作为产物：
  描述：

  1'-Hydroxy-6-phenyl-2,3-pyrido-Δ^4'-cyclopenten 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 以72.1%的产率得到7-oxo-2-phenyl-6,7-dihydro-5H-<1>pyridine
  参考文献：
  名称：

  Synthesis of chiral plane-extended pyridyl alcohols for the enantioselective addition of diethylzinc to aldehydes

  摘要：

  Enantiomerically pure pyridyl alcohols, 1 and 2, were prepared from readily available racemic pyridyl alcohol 3 and applied to the enantioselective addition of diethylzinc to aldehydes resulting in moderately high enantiomeric excess (90%) in the case of benzaldehyde. In this study the first example of an alteration in the configuration of the product upon change of a non-chiral and non-coordinating part of the catalyst was observed. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00247-5

文献信息

• Iron(ii)–bis(isonitrile) complexes: novel catalysts in asymmetric transfer hydrogenations of aromatic and heteroaromatic ketones
  作者：Anu Naik、Tapan Maji、Oliver Reiser

  DOI：10.1039/c0cc00508h

  日期：——

  Chiral iron(ii)-bis(isonitrile) complexes catalyse the transfer hydrogenation of aromatic ketones with enantioselectivities up to 91% ee, most likely via hydride transfer through imine intermediates, generated by in situ reduction of the isonitrile ligands, whereas iron acts as a Lewis acid to activate the ketone.

  手性铁（ii）-双（腈）配合物催化对映选择性高达91％ee的芳族酮的转移加氢反应，最有可能是通过原位还原异腈配体而通过亚胺中间体进行的氢化物转移，而铁起着路易斯酸激活酮。
• 有机化合物及含有其的有机电致发光器件
  申请人：北京鼎材科技有限公司

  公开号：CN112979650A

  公开（公告）日：2021-06-18

  一种有机化合物，具有如(I)所示的结构：其中，A和B各自独立为五元或六元环烷基；L为单键、取代或未取代的C6‑C30亚芳基或者取代或未取代的C3‑C30亚杂芳基；R1和R2各自独立地选自卤素、C1～C12烷基、C1～C12烷氧基、取代或未取代的C6‑C30芳基或者取代或未取代的C3～C30杂芳基；m和n分别为0～3的整数；Ar为取代或未取代的C6～C30芳基或者取代或未取代的C3～C30杂芳基，当Ar为氮杂芳基时，其至少有一个杂芳环上包含2个以上的N原子，在L为单键且Ar为芳基时，该取代基不为卤素。本发明进一步提供了前述有机化合物在有机电子器件中的应用，有助于提高有机电子器件的性能。
• Synthesis of chiral plane-extended pyridyl alcohols for the enantioselective addition of diethylzinc to aldehydes
  作者：Jahyo Kang、Ha Young Kim、Joong Hyup Kim

  DOI：10.1016/s0957-4166(99)00247-5

  日期：1999.7

  Enantiomerically pure pyridyl alcohols, 1 and 2, were prepared from readily available racemic pyridyl alcohol 3 and applied to the enantioselective addition of diethylzinc to aldehydes resulting in moderately high enantiomeric excess (90%) in the case of benzaldehyde. In this study the first example of an alteration in the configuration of the product upon change of a non-chiral and non-coordinating part of the catalyst was observed. (C) 1999 Elsevier Science Ltd. All rights reserved.