(R)-5-hydroxy-N-methylundecanamide | 1095329-14-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-5-hydroxy-N-methylundecanamide
• CAS: 1095329-14-8
• 化学式: C₁₂H₂₅NO₂
• 分子量: 215.336
• InChiKey: HCSYYLOARQQDLU-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  15.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  49.33
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (R)-5-hydroxy-N-methylundecanamide 在 对甲苯磺酸 、 sodium hydroxide 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 27.0h， 生成 (R)-δ-undecalactone
  参考文献：
  名称：

  Enantioselective Synthesis of δ-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction

  摘要：

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.

  DOI：

  10.1080/00397911.2010.529230
• 作为产物：
  描述：

  乙酸乙烯酯 、 5-hydroxy-N-methylundecanamide 在 Novozym 435 作用下， 以 乙醚 为溶剂， 反应 27.0h， 以44%的产率得到(R)-5-hydroxy-N-methylundecanamide
  参考文献：
  名称：

  Enantioselective Synthesis of δ-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction

  摘要：

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.

  DOI：

  10.1080/00397911.2010.529230