2,11-二氯十二烷-1,12-二酸 | 100525-23-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,11-二氯十二烷-1,12-二酸
• 英文名称: 2,11-dichloro dodecanoic-1,12-diacid
• 英文别名: 2,11-dichloro-dodecanedioic acid；2,11-Dichlor-dodecandisaeure；2,11-Dichlorododecanedioic acid
• CAS: 100525-23-3
• 化学式: C₁₂H₂₀Cl₂O₄
• 分子量: 299.194
• InChiKey: BBVDQHCJPYBKAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2,11-二氯十二烷-1,12-二酸 生成 2,11-Dichloro-dodecanedioic acid dimethyl ester
  参考文献：
  名称：

  Decyclization of chiorocyclohexanone hydroperoxides under the action of ferrous salts

  摘要：

  The decomposition of 2-chloro-, 2,2-dichloro-, and 2,6-dichloro-substituted cyclohexanone hydroperoxides on treatment with ferrous chloride and sulfate to give chloro-substituted aliphatic acids was investigated. A method for the synthesis of 2,6,6-trichlorohexanoic and 2,6,7,11-tetrachlorododecane-1,12-dioic acids was elaborated.

  DOI：

  10.1007/bf01433747
• 作为产物：
  描述：

  2-氯环己酮 在 甲醇 、 水 、 双氧水 、 iron(II) sulfate 作用下， 生成 2,11-二氯十二烷-1,12-二酸
  参考文献：
  名称：

  Structure of Peroxides Derived from Cyclohexanone and Hydrogen Peroxide¹

  摘要：

  DOI：

  10.1021/jo01103a021

文献信息

• METHOD FOR PRODUCING DIHYDROXYBENZENE DERIVATIVE
  申请人：Nagatomo Akinori

  公开号：US20110004013A1

  公开（公告）日：2011-01-06

  A method of producing a compound represented by the following general formula (3): [wherein R is a bivalent aliphatic group having a carbon number of 1-16 or a bivalent aromatic group], which comprises a step (i) of reacting a compound represented by the following general formula (1): with a carboxylic acid halide represented by the following general formula (2): [wherein R is a bivalent aliphatic group having a carbon number of 1-16 or a bivalent aromatic group and X is a halogen atom] in the presence of a basic compound to form an ester, and a step (ii) of conducting a heat treatment after the step (i) to decompose an oligomer in the ester.

  生产以下通用式（3）所代表的化合物的方法：[其中R是具有1-16个碳原子数的二价脂肪族基或二价芳香族基]，包括以下步骤：（i）将以下通用式（1）所代表的化合物与以下通用式（2）所代表的羧酸卤化物在碱性化合物存在下反应形成酯，以及（ii）在步骤（i）之后进行热处理以分解酯中的寡聚体。
• PROCESS FOR PRODUCING DIHYDROXYBENZENE DERIVATIVE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2269976A1

  公开（公告）日：2011-01-05

  This invention relates to a method of producing a compound represented by the following general formula (3): [wherein R is a bivalent aliphatic group having a carbon number of 1-16 or a bivalent aromatic group], which comprises a step (i) of reacting a compound represented by the following general formula (1): with a carboxylic acid halide represented by the following general formula (2): [wherein R is a bivalent aliphatic group having a carbon number of 1-16 or a bivalent aromatic group and X is a halogen atom] in the presence of a basic compound to form an ester, and a step (ii) of conducting a heat treatment after the step (i) to decompose an oligomer in the ester.

  本发明涉及一种生产由以下通式（3）代表的化合物的方法： [其中 R 为碳原子数为 1-16 的二价脂肪族基团或二价芳香族基团]，该方法包括步骤(i)：使下 列通式(1)所代表的化合物反应： 与以下通式（2）代表的羧酸卤化物反应： [其中 R 为碳原子数为 1-16 的二价脂肪族基团或二价芳香族基团，X 为卤素原子]，在碱性化合物存在下反应生成酯，以及步骤(ii)，在步骤(i)之后进行热处理以分解酯中的低聚物。
• PROCESS FOR PRODUCING CARBOXYLIC ACID CHLORIDE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2128122B1

  公开（公告）日：2014-01-22
• Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives
  作者：Christian V Stevens、Bart Vanderhoydonck

  DOI：10.1016/s0040-4020(01)00407-0

  日期：2001.5

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Polynuclear fused aromatic ring type polymer and preparation thereof
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0053937B1

  公开（公告）日：1985-06-19