N-((tert-butoxycarbonyl)amino)-N-methyl-D-leucine | 1197031-78-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((tert-butoxycarbonyl)amino)-N-methyl-D-leucine
• CAS: 1197031-78-9
• 化学式: C₁₂H₂₄N₂O₄
• 分子量: 260.334
• InChiKey: BTEOQIGBJQGFNJ-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  78.87
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-((tert-butoxycarbonyl)amino)-N-methyl-D-leucine 在 氯化亚砜 作用下， 以100%的产率得到methyl N-amino-N-methyl-D-leucinate hydrochloride
  参考文献：
  名称：

  Efficient synthesis of N-Me, N-Boc-protected α-hydrazinoacids: access to 1:1:1 [N-Me α-hydrazino/α/N-Me α-hydrazino]trimers

  摘要：

  The preparation of optically pure N-alpha-Me, N-beta-Boc-protected alpha-hydrazinoacids in large scale is described via a S(N)2 protocol. These compounds were used as starting materials for the synthesis of 1: 1:1 [N-alpha-Me alpha-hydrazino/alpha/N-alpha-Me alpha-hydrazino]trimers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.095
• 作为产物：
  描述：

  (R)-(-)-Nα-methyl-Nβ-Boc-(D)-hydrazinoleucine methyl ester 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 45.0h， 以95%的产率得到N-((tert-butoxycarbonyl)amino)-N-methyl-D-leucine
  参考文献：
  名称：

  Efficient synthesis of N-Me, N-Boc-protected α-hydrazinoacids: access to 1:1:1 [N-Me α-hydrazino/α/N-Me α-hydrazino]trimers

  摘要：

  The preparation of optically pure N-alpha-Me, N-beta-Boc-protected alpha-hydrazinoacids in large scale is described via a S(N)2 protocol. These compounds were used as starting materials for the synthesis of 1: 1:1 [N-alpha-Me alpha-hydrazino/alpha/N-alpha-Me alpha-hydrazino]trimers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.095