2-ethyl-3-hydroxy-succinic acid | 16048-76-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-ethyl-3-hydroxy-succinic acid
• 英文别名: 2-Aethyl-3-hydroxy-bernsteinsaeure；β-Ethyl-aepfelsaeure；2-Ethyl-3-hydroxybutanedioic acid
• CAS: 16048-76-3
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: JUCRENBZZQKFGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-ethyl-3-hydroxy-succinic acid 生成 monoethylmaleic acid
  参考文献：
  名称：

  母乳喂养和超重的风险。

  摘要：

  DOI：

  10.1001/jama.286.12.1448
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 2-ethyl-3-hydroxy-succinic acid
  参考文献：
  名称：

  Ingold, Journal of the Chemical Society, 1922, vol. 121, p. 2692

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING 3-AMINOMETHYLTETRAHYDROFURAN DERIVATIVE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1780205A1

  公开（公告）日：2007-05-02

  An object of the present invention is to provide a process for producing a 3-cyanotetrahydrofuran derivative in a high yield from inexpensive industrial materials. According to the present invention, a 3-aminomethyltetrahydrofuran derivative is produced by preparing a 3-cyanotetrahydrofuran derivative in a high yield from an inexpensive and industrially easily available malic acid derivative, and reducing the cyano group of the 3-cyanotetrahydrofuran derivative.

  本发明的一个目的是提供一种从廉价的工业原料中高产率生产3-氰基四氢呋喃衍生物的方法。根据本发明，通过从廉价且工业上易获得的苹果酸衍生物制备高产率的3-氰基四氢呋喃衍生物，然后还原3-氰基四氢呋喃衍生物的氰基，从而制备3-氨甲基四氢呋喃衍生物。
• BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS
  申请人：Liao James C.

  公开号：US20090081746A1

  公开（公告）日：2009-03-26

  Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate.

  本文提供了用于生产生物燃料的代谢修饰微生物。更具体地，本文提供了从适当底物中生产高醇类化合物的方法，包括异丁醇、1-丁醇、1-丙醇、2-甲基-1-丁醇、3-甲基-1-丁醇和2-苯乙醇。
• DESIGNER CALVIN-CYCLE-CHANNELED PRODUCTION OF BUTANOL AND RELATED HIGHER ALCOHOLS
  申请人：Lee James Weifu

  公开号：US20110177571A1

  公开（公告）日：2011-07-21

  Designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathways, the associated designer genes and designer transgenic photosynthetic organisms for photobiological production of butanol and related higher alcohols from carbon dioxide and water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer photosynthetic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathway gene(s) and biosafety-guarding technology for enhanced photobiological production of butanol and related higher alcohols from carbon dioxide and water.

  本发明提供了设计师卡尔文循环通道和光合作用NADPH增强途径、相关设计师基因和转基因光合生产丁醇和相关高级醇的生物体，这些生物体利用二氧化碳和水进行光生物生产。所述丁醇和相关高级醇包括1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和6-甲基-1-庚醇。设计师光合生产丁醇和相关高级醇的生物体，例如设计师转基因氧光合细菌和藻类，包括设计师卡尔文循环通道和光合作用NADPH增强途径基因和生物安全防护技术，以增强从二氧化碳和水中光生物生产丁醇和相关高级醇的产量。
• Designer Calvin-Cycle-Channeled and Hydrogenotrophic Production of Butanol and Related Higher Alcohols
  申请人：Lee James Weifu

  公开号：US20130344553A1

  公开（公告）日：2013-12-26

  Designer Calvin-cycle-channeled and hydrogenotrophic biofuel-production pathways, the associated designer genes and designer transgenic organisms for autotrophic production of butanol and related higher alcohols from carbon dioxide, hydrogen, and/or water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer autotrophic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and hydrogenotrophic pathway gene(s) and biosafety-guarding technology for enhanced autotrophic production of butanol and related higher alcohols from carbon dioxide and water.

  本发明提供了设计师Calvin循环通道和氢营养生物燃料生产途径，以及相关的设计师基因和设计师转基因生物，用于从二氧化碳、氢和/或水的自养生产丁醇和相关的高级醇。丁醇和相关的高级醇包括1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和6-甲基-1-庚醇。设计师自养生物，例如设计师转基因光合细菌和藻类，包括设计师Calvin循环通道和氢营养途径基因和生物安全保护技术，以增强从二氧化碳和水中自养生产丁醇和相关高级醇的能力。
• Designer Photoautotrophic and Hydrogenotrophic Production of Alcohols and Biodiesel
  申请人：Lee James Weifu

  公开号：US20150353961A1

  公开（公告）日：2015-12-10

  Designer Calvin-cycle-channeled and hydrogenotrophic biofuel-production pathways, the associated designer genes and designer transgenic organisms for autotrophic production of alcohols and biodiesel from carbon dioxide, hydrogen, and/or water are disclosed. The alcohols include methanol, ethanol, propanol, 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer autotrophic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and hydrogenotrophic pathway gene(s) and biosafety-guarding technology for enhanced autotrophic production of alcohols and biodiesel from carbon dioxide and water; wherein the designer transgenic cells in their mass liquid culture can inducibly self-flocculate for enhanced harvesting of their biomass upon the expression of the designer cell surface-linked positively charged polypeptides.

  公开了设计师卡尔文循环通道和氢营养生物燃料生产途径，相关的设计师基因和设计师转基因生物，用于自养生产醇类和生物柴油，从二氧化碳、氢和/或水中获取。醇类包括甲醇、乙醇、丙醇、1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和6-甲基-1-庚醇。设计师自养生物如设计师转基因氧合光合细菌和藻类包括设计师卡尔文循环通道和氢营养途径基因和生物安全保护技术，以增强从二氧化碳和水中自养生产醇类和生物柴油的能力。其中，设计师转基因细胞在其质量液体培养中可诱导自我絮凝，以增强表达设计师细胞表面连接的带正电的多肽后，收获其生物量。