4-<3-carbonyl-3-(succinimidyl)propyl>-4'-methyl-2,2'-bipyridine | 130699-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-<3-carbonyl-3-(succinimidyl)propyl>-4'-methyl-2,2'-bipyridine
• 英文别名: 4-(4'-methyl-[2,2']bipyridin-4-yl)-butyric acid succinimidyl ester；4-[3-carbonyl-3-(succinimidyl)propyl]-4'-methyl-2,2'-bipyridine；4-(4'-Methyl-[2,2']bipyridinyl-4-yl)-butyric acid succinimidyl ester；(2,5-dioxopyrrolidin-1-yl) 4-[2-(4-methylpyridin-2-yl)pyridin-4-yl]butanoate
• CAS: 130699-88-6
• 化学式: C₁₉H₁₉N₃O₄
• 分子量: 353.378
• InChiKey: AJBJDTZARNUALS-UHFFFAOYSA-N

物化性质

• 沸点：
  530.7±60.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,8-二氨基-3,6-二氧杂辛烷 、 4-<3-carbonyl-3-(succinimidyl)propyl>-4'-methyl-2,2'-bipyridine 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 N-(2-[2-(2-aminoethoxy)-ethoxy]-ethyl)-4-(4'-methyl-[2,2']bipyridin-4-yl)-butyramide
  参考文献：
  名称：

  A Mismatch-Selective Bifunctional Rhodium−Oregon Green Conjugate:  A Fluorescent Probe for Mismatched DNA

  摘要：

  A fluorescent metallointercalator conjugate that selectively targets DNA base mismatches has been synthesized by coupling an organic fluorophore to a bulky Rh intercalator containing the chrysenequinone diimine ligand. Ion pairing between the cationic Rh and anionic fluorophore moieties dramatically quenches the fluorescence of the conjugate in solution and in the presence of matched DNA. However, in the presence of mismatched DNA, the fluorescence of the conjugate is increased >300%. This increase in fluorescence is attributed to the loss in intramolecular quenching associated with DNA binding; intercalation of the Rh moiety into the mismatched site can lead to electrostatic repulsion of the anionic fluorophore away from the DNA phosphate backbone and Rh. Denaturing PAGE experiments with 32P-labeled oligonucleotides indicate that the conjugate selectively binds the mismatched DNA with a binding affinity of 6 x 105 M-1 and, upon irradiation, cleaves the DNA backbone neighboring the mismatched site.

  DOI：

  10.1021/ja061409c
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 4-甲基-4'-(3-羟丙基)-2,2'-双吡啶 在 N,N'-二环己基碳二亚胺 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以59%的产率得到4-<3-carbonyl-3-(succinimidyl)propyl>-4'-methyl-2,2'-bipyridine
  参考文献：
  名称：

  走向化学核糖核酸酶。2. 核苷-联吡啶偶联物的合成和表征。RNA 的铜 (II) 复合物水解裂解

  摘要：

  作为我们开发通过磷酸二酯水解切割 RNA 的化学核糖核酸酶的计划的一部分，描述了对共价连接的核苷-2,2'-联吡啶 (bpy) 偶联物​​的系统研究

  DOI：

  10.1021/ja00001a041

文献信息

• Compounds and methods for nucleic acid mismatch detection
  申请人：Barton K. Jacqueline

  公开号：US20070224612A1

  公开（公告）日：2007-09-27

  In accordance with the present invention there are provided sterically demanding intercalators. These compounds are useful for detection of a base-pair mismatch, such as by measuring fluorescence of complexes formed by the compounds of the invention and nucleic acid duplexes. The compounds are also capable of catalyzing photolytic cleavage of nucleic acids.

  根据本发明，提供了具有立体位阻的插入剂。这些化合物可用于检测碱基对不匹配，例如通过测量本发明化合物和核酸双链形成的复合物的荧光。这些化合物还能够催化光解核酸。
• MODAK, ANIL S.;GARD, JANICE K.;MERRIMAN, MICHAEL C.;WINKELER, KIMBERLY A.+, J. AMER. CHEM. SOC., 113,(1991) N, C. 283-291
  作者：MODAK, ANIL S.、GARD, JANICE K.、MERRIMAN, MICHAEL C.、WINKELER, KIMBERLY A.+

  DOI：——

  日期：——
• IMMUNOASSAY FOR SOLUBLE PD-L1
  申请人：Ayanoglu Gulesi

  公开号：US20160069900A1

  公开（公告）日：2016-03-10

  The present disclosure describes two matched antibody pairs for use in a sandwich immunoassay for detecting and quantifying soluble PD-L1 in liquid samples, as well as an electrochemiluminescence sandwich immunoassay that has been optimized and validated with one of the matched pairs.
• US7786298B2
  申请人：——

  公开号：US7786298B2

  公开（公告）日：2010-08-31
• [EN] COMPOUNDS AND METHODS FOR NUCLEIC ACID MISMATCH DETECTION<br/>[FR] COMPOSES ET PROCEDES DE DETECTION DES MESAPPARIEMENTS D'ACIDES NUCLEIQUES
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2007084380A2

  公开（公告）日：2007-07-26

  [EN] In accordance with the present invention there are provided sterically demanding intercalators. These compounds are useful for detection of a base-pair mismatch, such as by measuring fluorescence of complexes formed by the compounds of the invention and nucleic acid duplexes. The compounds are also capable of catalyzing photolytic cleavage of nucleic acids.
  [FR] La présente invention concerne des intercalateurs exigeants sur le plan stérique. Ces composés sont utiles pour la détection des mésappariements de paires de bases, telle que mesurée par la fluorescence des complexes formés par les composés de l'invention et les duplexes d'acides nucléiques. Les composés sont également capables de catalyser une coupure photolytique d'acides nucléiques.