DL-缬氨酸-15N | 71261-62-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: DL-缬氨酸-15N
• 英文名称: [15N]valine
• 英文别名: DL-Valine-15N；2-(15N)azanyl-3-methylbutanoic acid
• CAS: 71261-62-6
• 化学式: C₅H₁₁NO₂
• 分子量: 118.141
• InChiKey: KZSNJWFQEVHDMF-PTQBSOBMSA-N

物化性质

• 熔点：
  295 °C (subl.)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐-1,1-13C2 、 DL-缬氨酸-15N 生成
  参考文献：
  名称：

  Selective refocusing pulses in magic-angle spinning NMR: Characterization and applications to multi-dimensional protein spectroscopy

  摘要：

  Band-selective pulses are frequently used in multi-dimensional NMR in solution, but have been used relatively less often in solid-state NMR applications because of the complications imposed by magic-angle spinning. In this work, we examine the frequency profiles and the refocusing efficiency of several commonly employed selective general rotation pi pulses through experiments and numerical simulations. We demonstrate that highly efficient refocusing of transverse magnetization can be achieved, with experiments that agree well with numerical simulations. We also show that the rotational echo is shifted by a half rotor period if a selective pulse is applied over an integer number of rotor periods. Appropriately synchronizing indirect evolution periods with selective pulses ensures proper phasing of cross peaks in 2D spectra. The improved performance of selective pulses in multi-dimensional protein spectroscopy is demonstrated on the 56-residue beta 1 immunoglobulin binding domain of protein G (GBI). (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jmr.2005.12.003

文献信息

• Selective refocusing pulses in magic-angle spinning NMR: Characterization and applications to multi-dimensional protein spectroscopy
  作者：Ying Li、Benjamin J. Wylie、Chad M. Rienstra

  DOI：10.1016/j.jmr.2005.12.003

  日期：2006.4

  Band-selective pulses are frequently used in multi-dimensional NMR in solution, but have been used relatively less often in solid-state NMR applications because of the complications imposed by magic-angle spinning. In this work, we examine the frequency profiles and the refocusing efficiency of several commonly employed selective general rotation pi pulses through experiments and numerical simulations. We demonstrate that highly efficient refocusing of transverse magnetization can be achieved, with experiments that agree well with numerical simulations. We also show that the rotational echo is shifted by a half rotor period if a selective pulse is applied over an integer number of rotor periods. Appropriately synchronizing indirect evolution periods with selective pulses ensures proper phasing of cross peaks in 2D spectra. The improved performance of selective pulses in multi-dimensional protein spectroscopy is demonstrated on the 56-residue beta 1 immunoglobulin binding domain of protein G (GBI). (c) 2005 Elsevier Inc. All rights reserved.