2-cyano-N-methyl-4-(piperidin-4-ylmethoxy)-6-((spiro[4.5]decan-8-ylmethyl)amino)pyrimidine-5-carboxamide | 1181985-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-cyano-N-methyl-4-(piperidin-4-ylmethoxy)-6-((spiro[4.5]decan-8-ylmethyl)amino)pyrimidine-5-carboxamide
• CAS: 1181985-24-9
• 化学式: C₂₄H₃₆N₆O₂
• 分子量: 440.589
• InChiKey: DOLRJCLQADQMTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  32.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  111.96
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 2-cyano-N-methyl-4-(piperidin-4-ylmethoxy)-6-((spiro[4.5]decan-8-ylmethyl)amino)pyrimidine-5-carboxamide 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 2-cyano-N-methyl-4-((1-methylpiperidin-4-yl)methoxy)-6-(spiro[4.5]decan-8-ylmethylamino)pyrimidine-5-carboxamide
  参考文献：
  名称：

  Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

  摘要：

  We describe here orally active and brain-penetrant cathepsin S selective inhibitors, which are virtually devoid of hERG K(+) channel affinity, yet exhibit nanomolar potency against cathepsin S and over 100-fold selectivity to cathepsin L. The new non-peptidic inhibitors are based on a 2-cyanopyrimidine scaffold bearing a spiro[3.5] non-6-yl-methyl amine at the 4-position. The brain-penetrating cathepsin S inhibitors demonstrate potential clinical utility for the treatment of multiple sclerosis and neuropathic pain. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.067
• 作为产物：
  描述：

  tert-butyl 4-(((2-cyano-5-(methylcarbamoyl)-6-((spiro[4.5]decan-8-ylmethyl)amino)pyrimidin-4-yl)oxy)methyl)piperidine-1-carboxylate 在 盐酸 、 乙酸乙酯 作用下， 反应 0.5h， 以100%的产率得到2-cyano-N-methyl-4-(piperidin-4-ylmethoxy)-6-((spiro[4.5]decan-8-ylmethyl)amino)pyrimidine-5-carboxamide
  参考文献：
  名称：

  Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

  摘要：

  We describe here orally active and brain-penetrant cathepsin S selective inhibitors, which are virtually devoid of hERG K(+) channel affinity, yet exhibit nanomolar potency against cathepsin S and over 100-fold selectivity to cathepsin L. The new non-peptidic inhibitors are based on a 2-cyanopyrimidine scaffold bearing a spiro[3.5] non-6-yl-methyl amine at the 4-position. The brain-penetrating cathepsin S inhibitors demonstrate potential clinical utility for the treatment of multiple sclerosis and neuropathic pain. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.067