12-[1-(4-Methoxyphenyl)sulfonylindol-3-yl]dodecan-1-ol | 411218-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 12-[1-(4-Methoxyphenyl)sulfonylindol-3-yl]dodecan-1-ol
• CAS: 411218-10-5
• 化学式: C₂₇H₃₇NO₄S
• 分子量: 471.661
• InChiKey: UNUINOCIKLTLSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  33
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  76.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  12-[1-(4-Methoxyphenyl)sulfonylindol-3-yl]dodecan-1-ol 在 disodium hydrogenphosphate 、 sodium amalgam 作用下， 以 甲醇 为溶剂， 以83%的产率得到12-(1H-indol-3-yl)dodecan-1-ol
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616
• 作为产物：
  描述：

  1-(4-methoxyphenyl)sulfonyl-3-[(Z)-12-phenylmethoxydodec-1-enyl]indole 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.32 kPa 条件下， 以92%的产率得到12-[1-(4-Methoxyphenyl)sulfonylindol-3-yl]dodecan-1-ol
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616

文献信息

• Indole derivatives substituted with long-chain alcolhols and medicaments containing them
  申请人：Luu Bang

  公开号：US20050131053A1

  公开（公告）日：2005-06-16

  The invention relates to a flange coupling of two pipes, in particular the pipes of an exhaust system of a motor vehicle internal combustion engine. The coupling is characterized in that: each of the flanges is formed onto the corresponding pipe by the shaping of one of the pipe regions that form the respective flanges; a first of the two flanges is configured with a first connection pipe section, which engages radially in the interior of the second flange; a sealing ring is clamped between the flanges; the flanges are axially fixed by a clamping deice. The coupling is designed to be produced in an efficient manner, easy to mount and configured so that it functions reliably.

  本发明涉及两个管道的法兰联接，特别是内燃机汽车排气系统的管道。该联接的特点在于：每个法兰都是通过成形相应法兰的一段管道区域而形成在对应的管道上的；两个法兰中的第一个法兰配置有第一连接管道部分，该部分径向插入第二个法兰的内部；密封环夹紧在两个法兰之间；法兰由夹紧装置轴向固定。该联接设计为高效制造、易于安装并且配置使其功能可靠。
• Indole derivatives substituted with long-chain alcohols and medicaments containing them
  申请人：LUU Bang

  公开号：US20080234357A1

  公开（公告）日：2008-09-25

  Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

  提供的是一种吲哚长链醇，或其水合物或异构体，由以下公式（I）表示：其中R1、R2、R3和R4各自独立地表示氢原子、甲基基团、乙酰基团或羟基团，n表示从0到20的数字;以及包含该物质的药物组合物。该吲哚长链醇（I）表现出出色的神经生长促进效果，以及强效的抗氧化和抗肿瘤效果，因此可用作预防和/或治疗脑部疾病，包括痴呆症，以及恶性肿瘤，包括脑肿瘤的预防和/或治疗剂。
• INDOLE DERIVATIVES SUBSTITUTED WITH LONG-CHAIN ALCOHOLS AND MEDICAMENTS CONTAINING THEM
  申请人：Meiji Dairies Corporation

  公开号：EP1474390B1

  公开（公告）日：2009-07-22
• US7407983B2
  申请人：——

  公开号：US7407983B2

  公开（公告）日：2008-08-05
• US7902249B2
  申请人：——

  公开号：US7902249B2

  公开（公告）日：2011-03-08