1,7-Bis(p-hydroxyphenyl)heptanon-4 | 33617-74-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1,7-Bis(p-hydroxyphenyl)heptanon-4
• 英文别名: 1,7-Bis(4-hydroxyphenyl)heptan-4-one
• CAS: 33617-74-2
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: RJYQSBZWJQBWBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(4-甲氧基苯基)丁腈 在 硫酸 、 苯基锂 、 N-甲基苯胺 作用下， 以 乙醚 为溶剂， 生成 1,7-Bis(p-hydroxyphenyl)heptanon-4
  参考文献：
  名称：

  Preparation of 1,7-Bis(p-hydroxyphenyl)heptane

  摘要：

  DOI：

  10.1246/bcsj.44.1986

文献信息

• [EN] PREPARATION OF 2-(4-ETHOXYPHENYL)-2-METHYLPROPYL ALCOHOL<br/>[FR] ELABORATION DE 2-(4-ETHOXYPHENYL)-2-METHYL PROPYL ALCOOL
  申请人：RPG LIFE SCIENCES LTD

  公开号：WO2001044151A1

  公开（公告）日：2001-06-21

  A process for the preparation of 2-(4-ethoxyphenyl)-2-methyl propyl alcohol comprising the steps of acylating phenol to give phenyl isobutyrate; subjecting said phenyl isobutyrate to Fries rearrangement to give 4-hydroxyphenyl-α-methylethyl ketone; ethylating said 4-hydroxyphenyl-α-methylethyl ketone to give 4-ethoxyphenyl-α-methylethyl ketone; halogenating said 4-ethoxyphenyl-α-methylethyl ketone to give 4-ethoxyphenyl-α-halo-α-methylethyl ketone; converting said halo ketone to halo ketal, subjecting said ketal to rearrangement to obtain an intermediate and hydrolysing the said intermediate to obtain 2-(4-ethoxyphenyl)-2-methyl propionic acid; converting said 2-(4-ethoxyphenyl)-2-methyl propionic acid to 2-(4-ethoxyphenyl)-2-methyl propionic acid alkyl ester, and treating said alkyl ester with an alkali metal in the presence of an alcohol to give 2-(4-ethoxyphenyl)-2-methyl propyl alcohol.

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