N-[5-(2-aminoethylcarbamoyl)-1-methylpyrrol-3-yl]-1-methylimidazole-2-carboxamide | 1179539-36-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[5-(2-aminoethylcarbamoyl)-1-methylpyrrol-3-yl]-1-methylimidazole-2-carboxamide
• CAS: 1179539-36-6
• 化学式: C₁₃H₁₈N₆O₂
• 分子量: 290.325
• InChiKey: AYBZFLSSPXEORK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[5-(2-aminoethylcarbamoyl)-1-methylpyrrol-3-yl]-1-methylimidazole-2-carboxamide 、 Sdex-isothiocyanate 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-[5-[2-[2-[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]sulfanylethylcarbamothioylamino]ethylcarbamoyl]-1-methylpyrrol-3-yl]-1-methylimidazole-2-carboxamide
  参考文献：
  名称：

  Investigation of the Relative Cellular Permeability of DNA-Binding Pyrrole−Imidazole Polyamides

  摘要：

  Pyrrole-imidazole (Py-Im) polyamides are a group of chemicals that are able to bind specifically to DNA sequences in vitro and in mammalian cells. Using a cell based reporter assay, we investigated the size and linker affects on the cellular permeability of polyamides. We found that the conventional beta-alanine-3,3'-diamino-N-methyldipropylamine (beta Da) linker strongly limited the cellular permeability. We discovered that a short ethylene diamine (Et) linker displayed high cellular permeability. With the improved Et linker, we found that the cellular permeability of polyamides was size-dependent.

  DOI：

  10.1021/jm9002999