N-Boc-4-isocyanatobutylamine | 851682-52-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Boc-4-isocyanatobutylamine
• 英文别名: tert-butyl N-(4-isocyanatobutyl)carbamate
• CAS: 851682-52-5
• 化学式: C₁₀H₁₈N₂O₃
• 分子量: 214.265
• InChiKey: DTSDHUMPJGCTPZ-UHFFFAOYSA-N

物化性质

• 熔点：
  84 °C
• 沸点：
  320.9±25.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氨基喹啉 、 N-Boc-4-isocyanatobutylamine 生成
  参考文献：
  名称：

  2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges

  摘要：

  We have demonstrated that aromatic heterocycles having hydrogen-bonding surfaces complementary to those of nucleotide bases are effective molecular elements for the binding to single nucleotide bulges and base mismatches. We here report that a new molecule, 2-ureidoquinoline having an alignment of hydrogen-bonding groups in the order of acceptor-donor-donor stabilizes single cytosine and thymine bulges in duplex DNAs. Furthermore, a dimeric form of 2-ureidoquinoline stabilizes cytosine-cytosine and cytosine-thymine mismatches. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.075
• 作为产物：
  描述：

  Boc-5-氨基戊酸 在 二苯基膦叠氮化物 作用下， 生成 N-Boc-4-isocyanatobutylamine
  参考文献：
  名称：

  2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges

  摘要：

  We have demonstrated that aromatic heterocycles having hydrogen-bonding surfaces complementary to those of nucleotide bases are effective molecular elements for the binding to single nucleotide bulges and base mismatches. We here report that a new molecule, 2-ureidoquinoline having an alignment of hydrogen-bonding groups in the order of acceptor-donor-donor stabilizes single cytosine and thymine bulges in duplex DNAs. Furthermore, a dimeric form of 2-ureidoquinoline stabilizes cytosine-cytosine and cytosine-thymine mismatches. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.075

文献信息

• Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
  申请人：Sharma D. Shubh

  公开号：US20050124636A1

  公开（公告）日：2005-06-09

  A thienopyrimidine compound of the formula: wherein R 1 , R 2 , R 3 , and R 4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-associated disorders.

  式中的噻吩嘧啶化合物： 其中 R 1 , R 2 , R 3 和 R 4 以及使用此类化合物治疗黑色素皮质素受体相关疾病的方法。
• NOVEL PYRROLE DERIVATIVES WITH HISTONE DEACETYLASE INHIBITOR ACTIVITY
  申请人：UNIVERSIDAD DEL PAIS VASCO-EUSKAL HERRIKO UNIBERSITATEA

  公开号：EP1975158B9

  公开（公告）日：2012-02-29
• Synthesis and Characterization of Segmented Copoly(ether urea)s with Uniform Hard Segments
  作者：Ron M. Versteegen、Rint P. Sijbesma、E. W. Meijer

  DOI：10.1021/ma0478207

  日期：2005.4.1

  Employing protective group strategy and novel isocyanate chemistry, segmented copoly(ether urea)s with uniform hard segments were prepared. Amine-terminated poly(tetrahydrofuran) served as the soft segment of these polymers. The size of the hard segments and the number of urea groups it contains were varied systematically, and their influence on the properties was investigated. The strength of hydrogen bonding between the urea groups in monodisperse hard segments containing exactly 1 to exactly 4 urea groups was studied by infrared spectroscopy and compared with materials containing polydisperse hard segments. The strength of hydrogen bonding in polymers possessing exactly two urea groups per hard segment resulted in an optimal balance between excellent mechanical properties and good processability and solubility.
• Pyrrolic Derivatives with Histone Deacetylase Inhibitory Activity
  申请人：Cossio Mora Fernando Pedro

  公开号：US20080262073A1

  公开（公告）日：2008-10-23

  The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.
• US7638550B2
  申请人：——

  公开号：US7638550B2

  公开（公告）日：2009-12-29