p-[(tert-butyldimethylsilyl)oxy]benzyl trifluoroacetate | 156878-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-[(tert-butyldimethylsilyl)oxy]benzyl trifluoroacetate
• 英文别名: 4-<(tert-Butyldimethylsilyl)oxy>benzyl trifluoroacetate；4-{(t-Butyldimethylsilyl)oxy}benzyl trifluoroacetate；4-tertiobutyldimethylsiloxybenzyl trifluoroacetate；[4-[tert-butyl(dimethyl)silyl]oxyphenyl]methyl 2,2,2-trifluoroacetate
• CAS: 156878-45-4
• 化学式: C₁₅H₂₁F₃O₃Si
• 分子量: 334.411
• InChiKey: UXABBPKUSXYVAF-UHFFFAOYSA-N

物化性质

• 沸点：
  302.6±42.0 °C(Predicted)
• 密度：
  1.111±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.68
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  p-[(tert-butyldimethylsilyl)oxy]benzyl trifluoroacetate 以 四氢呋喃 为溶剂， 反应 14.0h， 生成 (4-(bromomethyl)phenoxy)(tert-butyl)dimethylsilane
  参考文献：
  名称：

  新型次甲基官能化和树枝状 C-蝎形化合物。

  摘要：

  螯合配体的研究无疑是化学中最重要的研究领域之一。目前的工作旨在合成三足C-蝎酸酯化合物的新功能化衍生物。Tris-2,2,2-(1-吡唑基)乙醇，HOCH2C(pz)₃ (1)，氢化三(吡唑基)甲烷最重要的衍生物之一，被用作合成新型官能化C的结构单元-蝎子酸盐，旨在扩大此类未经探索的化合物的范围。第一个树枝状C-蝎子酸酯被成功制备并用于重要的工业催化反应Sonogashira和Heck CC交叉偶联。

  DOI：

  10.3390/molecules23123066
• 作为产物：
  描述：

  4-[[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]-苯甲醇 在 三氟乙酸酐 、 苯甲醇 作用下， 以 四氢呋喃 为溶剂， 以98%的产率得到p-[(tert-butyldimethylsilyl)oxy]benzyl trifluoroacetate
  参考文献：
  名称：

  C-linked analogs of N-(4-hydroxyphenyl) retinamide

  摘要：

  本发明公开了一种酸稳定的I式化合物：##STR1##以及含有该化合物作为活性成分的制药组合物，以及通过向需要治疗癌症的哺乳动物，包括人类，的受试者施用一种或多种化合物的方法。这些化合物对酸水解具有抗性。

  公开号：

  US06117845A1

文献信息

• Use of Dendrimers to Stimulate Cell Growth
  申请人：Majoral Jean-Pierre

  公开号：US20090142316A1

  公开（公告）日：2009-06-04

  The present invention relates to the use of dendrimers with monophosphonic or bisphosphonic terminations in order to stimulate the growth of cell cultures or to activate cells in culture.

  本发明涉及在细胞培养中使用具有单磷酸或双磷酸端基的树枝状聚合物，以促进细胞培养的生长或激活细胞。
• 5-Pyrrolidinylsulfonyl Isatins as a Potential Tool for the Molecular Imaging of Caspases in Apoptosis
  作者：Klaus Kopka、Andreas Faust、Petra Keul、Stefan Wagner、Hans-Jörg Breyholz、Carsten Höltke、Otmar Schober、Michael Schäfers、Bodo Levkau

  DOI：10.1021/jm051217c

  日期：2006.11.1

  Caspases are the unique enzymes responsible for the execution of the cell death program and may represent an exclusive target for the specific molecular imaging of apoptosis in vivo. 5-Pyrrolidinylsulfonyl isatins represent potent nonpeptidyl caspase inhibitors that may be suitable for the development of caspase binding radioligands ( CBRs). ( S)-5-[ 1-(2-Methoxymethylpyrrolidinyl) sulfonyl] isatin ( 7) served as a lead compound for modification of its N-1-position. Corresponding pairs of N-1-substituted 2-methoxymethyl- and 2-phenoxymethylpyrrolidinyl derivatives were examined in vitro by biochemical caspase inhibition assays. All target compounds possess high in vitro caspase inhibtion potencies in the nanomolar to subnanomolar range for caspase-3 ( K-i = 0.2- 56.1 nM). As shown for compound ( S)-1-( 4-(2-fluoroethoxy) benzyl)-5-[ 1( 2-methoxymethylpyrrolidinyl) sulfonyl] isatin ( 35), the class of N-1-substituted 5-pyrrolidinylsulfonyl isatins competitively inhibits caspase-3. All caspase inhibitors show selectivity for the effector caspases-3 and -7 in vitro. The 2-methoxymethylpyrrolidinyl versions of the isatins appear to possess superior caspase inhibition potencies in cellular apoptosis inhibition assays compared with the 2-phenoxymethylpyrrolidinyl inhibitors.
• Potential Photoaffinity Labels for Tubulin. Synthesis and Evaluation of Diazocyclohexadienone and Azide Analogs of Colchicine, Combretastatin, and 3,4,5-Trimethoxybiphenyl
  作者：John D. Olszewski、Mary Marshalla、Michal Sabat、Richard J. Sundberg

  DOI：10.1021/jo00094a048

  日期：1994.7

  Analogs of tubulin assembly inhibitors such as colchicine, combretastatin, and 3,4,5-trimethoxybiphenyl which incorporate a 6-diazo-2,4-cyclohexadienone (o-quinone diazide) ring have been synthesized and characterized. The compounds synthesized include 6-diazo-4-(2',3',4'-trimethoxyphenyl)cyclohexa-2,4-dien-1-one and its 3-methyl and 3-ethyl analogs (1a-c), 6-diazo-3-(2,3,4-trimethoxyphenyl)-2,4-cyclohexadien-1-one and its 4-methyl and 4-ethyl derivatives (2a-c), 4-[Z-2-(3',4',5'-trimethoxyphenyl)ethenyl]-6-diazocyclohexa-2,4-dienone (3), 3-[Z-2-(3',4',5'-trimethoxyphenyl)ethenyl]-6-diazocyclohexa-2,4-dien-1-one (4), the corresponding dihydro derivatives (5, 6) and two isomeric diazocyclohexadienones derived from N-acetylcolchinol (7, 8). Compounds in which the cyclohexadienone oxygen is approximately isostructural with carbonyl or hydroxy functions of the parent compounds exhibit good activity in the tubulin assembly inhibition assay. 2'-Alkyl-4'azido-3,4,5-trimethoxy-1,1'-biphenyls also show good activity as tubulin assembly inhibitors.
• An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide
  作者：Kevin L Weiss、Galal Alshafie、Jason S Chapman、Serena M Mershon、Hussein Abou-Issa、Margaret Clagett-Dame、Robert W Curley

  DOI：10.1016/s0960-894x(01)00230-x

  日期：2001.6

  The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions although a potentially relevant and desirable difference is its reduced suppression of plasma vitamin A levels. These results show that 4-HPR does not have to be hydrolyzed to retinoic acid to produce its chemotherapeutic effects. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Novel Methinic Functionalized and Dendritic C-Scorpionates
  作者：Luísa Martins、Riccardo Wanke、Telma Silva、Armando Pombeiro、Paul Servin、Régis Laurent、Anne-Marie Caminade

  DOI：10.3390/molecules23123066

  日期：——

  fields of research in chemistry. The present work is directed to the synthesis of new functionalized derivatives of tripodal C-scorpionate compounds. Tris-2,2,2-(1-pyrazolyl)ethanol, HOCH₂C(pz)₃ (1), one of the most important derivatives of hydrotris(pyrazolyl)methane, was used as a building block for the synthesis of new functionalized C-scorpionates, aiming to expand the scope of this unexplored class

  螯合配体的研究无疑是化学中最重要的研究领域之一。目前的工作旨在合成三足C-蝎酸酯化合物的新功能化衍生物。Tris-2,2,2-(1-吡唑基)乙醇，HOCH2C(pz)₃ (1)，氢化三(吡唑基)甲烷最重要的衍生物之一，被用作合成新型官能化C的结构单元-蝎子酸盐，旨在扩大此类未经探索的化合物的范围。第一个树枝状C-蝎子酸酯被成功制备并用于重要的工业催化反应Sonogashira和Heck CC交叉偶联。