methoxy-1-methyl-1H-indole | 114113-16-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methoxy-1-methyl-1H-indole
• 英文别名: 2-Methoxy-1-methyl-1H-indole；2-methoxy-1-methylindole
• CAS: 114113-16-5
• 化学式: C₁₀H₁₁NO
• 分子量: 161.203
• InChiKey: ADCXVOYRRXVHHF-UHFFFAOYSA-N

物化性质

• 沸点：
  285.6±13.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  triethyl 1,2,4-triazine-3,5,6-tricarboxylate 、 methoxy-1-methyl-1H-indole 以 甲苯 为溶剂， 反应 36.0h， 以74%的产率得到9-Methyl-γ-carbolin-1,2,4-tricarbonsaeure-triethylester
  参考文献：
  名称：

  Moehrle, Hans; Dwuletzki, Heinz, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1987, vol. 42, # 8, p. 1032 - 1034

  摘要：

  DOI：

文献信息

• [EN] AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] DERIVES AMIDE EN TANT QU'INHIBITEURS D'HISTONE DEACETYLASE
  申请人：LETTI SPA ISTITUTO DI RICERCHE

  公开号：WO2006005955A1

  公开（公告）日：2006-01-19

  The present invention relates to carboxylic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

  本发明涉及一种抑制组蛋白去乙酰化酶（HDAC）的羧酸衍生物。本发明的化合物可用于治疗细胞增殖性疾病，包括癌症。此外，本发明的化合物还可用于治疗神经退行性疾病、精神分裂症、中风等其他疾病。
• Amide Derivatives as Inhibitors of Histone Deacetylase
  申请人：Chakravarty Prasun K.

  公开号：US20080262035A1

  公开（公告）日：2008-10-23

  The present invention relates to carboxylic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

  本发明涉及一种能够抑制组蛋白去乙酰化酶（HDAC）的羧酸衍生物。本发明的化合物可用于治疗细胞增殖性疾病，包括癌症。此外，本发明的化合物还可用于治疗神经退行性疾病、精神分裂症和中风等其他疾病。
• 5/5-OR 5/6-MEMBERED CONDENSED RING CYCLOALKYLAMINE DERIVATIVE
  申请人：Kishino Hiroyuki

  公开号：US20110124674A1

  公开（公告）日：2011-05-26

  Disclosed are a compound of a formula (I) and its pharmaceutically-acceptable salt: wherein Q is CH or N; R 1a , R 1b , R 1c and R 1d are independently a C 1-6 alkyl, a halo-C 1-6 alkyl, etc.; R 2 is a hydrogen atom, etc.; R 3 is independently a hydrogen atom, a C 1-6 alkyl, etc., or two R 3 's, taken together, form a bridge such as methylene, etc.; R 4a and R 4b are independently a hydrogen atom, a C 1-6 alkyl, etc.; Z is a bicyclic aromatic hetero ring, etc.; Ar is a benzene ring, etc.; m1 and m2 are independently 0, 1 or 2; n is an integer of from 1 to 4. The compound and its salt act as a melanin concentrating hormone receptor antagonist, and are useful as a preventive or remedy for central system disorders, cardiovascular disorders, metabolic disorders, etc.

  本发明公开了一种化合物及其药学上可接受的盐，其化学式为（I）： 其中，Q是CH或N；R1a，R1b，R1c和R1d独立地表示C1-6烷基，卤代C1-6烷基等；R2是氢原子等；R3独立地表示氢原子，C1-6烷基等，或者两个R3共同形成例如亚甲基等的桥；R4a和R4b独立地表示氢原子，C1-6烷基等；Z是双环芳香杂环，等；Ar是苯环等；m1和m2独立地表示0、1或2；n是1至4的整数。该化合物及其盐作为黑色素浓集激素受体拮抗剂，可用于预防或治疗中枢系统疾病、心血管疾病、代谢性疾病等。
• AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE
  申请人：Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.

  公开号：EP1768956A1

  公开（公告）日：2007-04-04
• US3959310A
  申请人：——

  公开号：US3959310A

  公开（公告）日：1976-05-25