2,6-dioxo-heptanedioic acid diethyl ester | 91353-51-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-dioxo-heptanedioic acid diethyl ester
• 英文别名: 2,6-Dioxo-heptandisaeure-diaethylester；1,5-Diaethoxycarbonyl-pentan-1,5-dion；Diethyl 2,6-dioxoheptanedioate
• CAS: 91353-51-4
• 化学式: C₁₁H₁₆O₆
• 分子量: 244.244
• InChiKey: YLINTWZIWFCISA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,6-dioxo-heptanedioic acid diethyl ester 在 乙醇 、 氨 、 镍 作用下， 100.0 ℃ 、9.81 MPa 条件下， 生成 2,6-dihydroxy-heptanedioic acid diamide
  参考文献：
  名称：

  Elimination of Latently HIV-1-Infected Cells by Lymphoblasts Armed with Bifunctional Antibody

  摘要：

  AbstractThe Fab′ fragment of a monoclonal antibody (mAb) to CD3 and the F(ab′)2 fragment of a mAb to human immunodeficiency virus 1 (HIV‐1) gp41 were combined to generate a bifunctional antibody (BFA). The mAb to gp41 (IV1‐4G6) has previously been shown to react with a number of HIV‐1 strains and T‐lymphoblastoid cells (TLBC) armed with the BFA (BFA‐TLBC) effectively inhibited HIV‐1 in primarily cultured lymphoblasts infected with the clinically isolated virus which was reactive to the mAb. Although BFA‐TLBC could not cause cytolysis of 51Cr‐labeled latently infected cells (OM‐10.1) in 6 hr incubation, cocultivation of OM‐10.1 cells with BFA‐TLBC for 3 days or more eliminated the latently infected cells making the cells susceptible to BFA‐TLBC. Therefore, BFA‐TLBC may be beneficial for HIV‐infected patients in eradicating latently infected cells which can not be eliminated even with highly active antiretroviral therapy (HAART).

  DOI：

  10.1111/j.1348-0421.2001.tb01266.x
• 作为产物：
  描述：

  1,7-diethoxy-hepta-1,6-diyne 在 氧气 、 臭氧 作用下， 以 正己烷 为溶剂， 生成 2,6-dioxo-heptanedioic acid diethyl ester
  参考文献：
  名称：

  Wisaksono,W.W.; Arens,J.F., Recueil des Travaux Chimiques des Pays-Bas, 1961, vol. 80, p. 846 - 848

  摘要：

  DOI：

文献信息

• Blaise; Gault, Bulletin de la Societe Chimique de France, 1907, vol. <4> 1, p. 30,78
  作者：Blaise、Gault

  DOI：——

  日期：——
• Onno, Journal des Recherches du Centre National de la Recherche Scientifique, 1960, vol. 11, p. 205,223
  作者：Onno

  DOI：——

  日期：——
• LITHOGRAPHIC PRINTING PLATE PRECURSOR
  申请人：AGFA GRAPHICS NV

  公开号：US20160282718A1

  公开（公告）日：2016-09-29

  A lithographic printing plate precursor includes (i) a support having a hydrophilic surface or which is provided with a hydrophilic layer, and (ii) a coating including a photopolymerisable layer, characterised in that the photopolymerisable layer includes a compound including at least one free radically polymerisable group and at least one moiety having a structure according to Formula (I): wherein X represents O or NR* and R* represents hydrogen, an optionally substituted alkyl, aryl, aralkyl or heteroaryl group; and * denotes the linking positions to the rest of the compound.