1-(2,5-Dioxopyrrolidin-1-yl) 8-methyl octanedioate | 1609637-03-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-(2,5-Dioxopyrrolidin-1-yl) 8-methyl octanedioate
• 英文别名: 8-O-(2,5-dioxopyrrolidin-1-yl) 1-O-methyl octanedioate
• CAS: 1609637-03-7
• 化学式: C₁₃H₁₉NO₆
• 分子量: 285.297
• InChiKey: TZCDVIBUNGOBJM-UHFFFAOYSA-N

物化性质

• 沸点：
  383.1±44.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(2,5-Dioxopyrrolidin-1-yl) 8-methyl octanedioate 在 O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 、 sodium hydroxide 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.58h， 生成 8-((4-((4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamoyl)benzyl)amino)-8-oxooctanoic acid
  参考文献：
  名称：

  Luminescent Lanthanide Cryptates: from the Bench to the Bedside

  摘要：

  The design and application of luminescent lanthanide cryptates for sensing biological interactions is highlighted through the review of the work performed in our laboratory and with academic collaborations. The path from the initial applications probing biochemical interaction in vitro to "state-of-the-art" cellular assays toward clinical applications using homogeneous time-resolved fluorescence technology is described. An overview of the luminescent lanthanide macrocyclic compounds developed at Cisbio in the recent past is given with an emphasis on specific constraints required by specific applications. Recent assays for drug-discovery and diagnostic purposes using both antibody-based and suicide-enzyme-based technology are illustrated. New perspectives in the field of molecular medicine and time-resolved microscopy are discussed.

  DOI：

  10.1021/ic402234k