2-Methoxy-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>benzoic acid methyl ester | 154187-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methoxy-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>benzoic acid methyl ester
• 英文别名: Methyl 2-methoxy-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoate；methyl 2-methoxy-5-[3-(trifluoromethyl)diazirin-3-yl]benzoate
• CAS: 154187-51-6
• 化学式: C₁₁H₉F₃N₂O₃
• 分子量: 274.199
• InChiKey: DGWYZNDPDHHUSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.2
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-Methoxy-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>benzoic acid methyl ester 在 chloroamine-T 、 三溴化硼 、 sodium iodide 作用下， 以 甲醇 、 正戊烷 为溶剂， 反应 0.5h， 生成 2-Hydroxy-3-iodo-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>benzoic acid methyl ester
  参考文献：
  名称：

  A Novel Family of Aromatic Diazirines for Photoaffinity Labeling

  摘要：

  A series Of simple methods for modifying diazirines bearing an aromatic ring has been accomplished. This first versatile approach involving direct substitution on the aromatic ring of diazirines has been achieved by means of the aromatic thallation of (alkoxyphenyl)diazirines. Introduction of the thallium moiety was successfully followed by nitration, iodination, or palladium-catalyzed carbonylation to give a family of substituted aryldiazirines useful for photolabeling. For instance, diazirines labeled with a nitro group can be detected by spectrophotometric methods, and those labeled with an iodo group can be useful in tracer experiments. The (methoxyphenyl)diazirines were also found to be stable under certain demethylation conditions, thus providing a potential source of diazirines with modifiable phenol hydroxyl groups. By means of this approach, a spacer arm to link diazirines with ligands was readily introduced. Radioactive diazirines labeled with carbon-14 or tritium were also prepared using this method. All the new diazirines were derived from a pair of simple (methoxyphenyl)diazirines. The ease of derivatization of the (alkoxyphenyl)diazirines described here may offer a practical approach to simplify the time-consuming methods currently used for diazirine synthesis.

  DOI：

  10.1021/jo00081a017
• 作为产物：
  描述：

  3-(4-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine 、 Thallium tris(trifluoroacetate) 以62%的产率得到
  参考文献：
  名称：

  Hatanaka Yasumaru, Hashimoto Makoto, Kurihara Hiroko, Nakayama Hitoshi, K+, J. Org. Chem, 59 (1994) N 2, S 383-387

  摘要：

  DOI：

文献信息

• Hatanaka Yasumaru, Hashimoto Makoto, Kurihara Hiroko, Nakayama Hitoshi, K+, J. Org. Chem, 59 (1994) N 2, S 383-387
  作者：Hatanaka Yasumaru, Hashimoto Makoto, Kurihara Hiroko, Nakayama Hitoshi, K+

  DOI：——

  日期：——
• A Novel Family of Aromatic Diazirines for Photoaffinity Labeling
  作者：Yasumaru Hatanaka、Makoto Hashimoto、Hiroko Kurihara、Hitoshi Nakayama、Yuichi Kanaoka

  DOI：10.1021/jo00081a017

  日期：1994.1

  A series Of simple methods for modifying diazirines bearing an aromatic ring has been accomplished. This first versatile approach involving direct substitution on the aromatic ring of diazirines has been achieved by means of the aromatic thallation of (alkoxyphenyl)diazirines. Introduction of the thallium moiety was successfully followed by nitration, iodination, or palladium-catalyzed carbonylation to give a family of substituted aryldiazirines useful for photolabeling. For instance, diazirines labeled with a nitro group can be detected by spectrophotometric methods, and those labeled with an iodo group can be useful in tracer experiments. The (methoxyphenyl)diazirines were also found to be stable under certain demethylation conditions, thus providing a potential source of diazirines with modifiable phenol hydroxyl groups. By means of this approach, a spacer arm to link diazirines with ligands was readily introduced. Radioactive diazirines labeled with carbon-14 or tritium were also prepared using this method. All the new diazirines were derived from a pair of simple (methoxyphenyl)diazirines. The ease of derivatization of the (alkoxyphenyl)diazirines described here may offer a practical approach to simplify the time-consuming methods currently used for diazirine synthesis.