[EN] CHROMENONE COMPOUNDS AS PI 3 -KINASE INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS DE CHROMÉNOME EN TANT QU'INHIBITEURS DE PI3-KINASE DESTINÉS AU TRAITEMENT DU CANCER
申请人:ASTRAZENECA AB
公开号:WO2012140419A1
公开(公告)日:2012-10-18
The invention concerns chromenone compounds of Formula I; or pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, n and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
The invention concerns chromenone compounds of Formula I;
or pharmaceutically-acceptable salts thereof, wherein each of R
1
, R
2
, R
3
, R
4
, R
5
, n and R
6
has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES
申请人:Winzeler Elizabeth
公开号:US20100056494A1
公开(公告)日:2010-03-04
The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with kinase activity, particularly malaria.
COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS
申请人:Cheng Dai
公开号:US20090312308A1
公开(公告)日:2009-12-17
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.