5''-Acetylamino-2''-methyl-biphenyl-4-carboxylic acid cyclopropylmethyl-amide | 515812-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5''-Acetylamino-2''-methyl-biphenyl-4-carboxylic acid cyclopropylmethyl-amide
• 英文别名: 4-(5-acetamido-2-methylphenyl)-N-(cyclopropylmethyl)benzamide
• CAS: 515812-78-9
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.407
• InChiKey: BRLLCVKXFXTCBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide 、 溶剂黄146 在 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 5''-Acetylamino-2''-methyl-biphenyl-4-carboxylic acid cyclopropylmethyl-amide
  参考文献：
  名称：

  Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity

  摘要：

  The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.

  DOI：

  10.1016/j.bmcl.2008.06.048

文献信息

• 5-acylamino-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
  申请人：——

  公开号：US20040242868A1

  公开（公告）日：2004-12-02

  Compounds of formula (I): 1 or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.

  化学式为(I)的化合物1或其药学上可接受的盐或溶剂，以及它们作为药物的用途，特别是作为p38激酶抑制剂。
• In-mold-coated automotive interior and other products, and methods for manufacturing same
  申请人：Shane Kyle

  公开号：US10144157B2

  公开（公告）日：2018-12-04

  Described are in-mold coated products such as vehicular components, in-mold coating methods, and in-mold coating compositions, involving the use of aqueous acrylic copolymer dispersions, desirably self-crosslinking.

  描述了模内涂覆产品（如车辆部件）、模内涂覆方法和模内涂覆组合物，其中涉及丙烯酸共聚物水性分散体的使用，最好是自交联的丙烯酸共聚物水性分散体。
• AQUEOUS SELF-CROSSLINKING COPOLYMER DISPERSIONS, A PROCESS FOR PREPARING THEM AND THEIR USE IN BINDERS FOR COATING MATERIALS
  申请人：——

  公开号：US20020147262A1

  公开（公告）日：2002-10-10

  Aqueous self-crosslinking copolymer dispersions ABC obtainable by free-radically initiated copolymerization in the first stage of a monomer mixture A comprising olefinically unsaturated monomers A1 having carbonyl groups, unsaturated carboxylic acids or monoesters of unsaturated dicarboxylic acids A2, monomers A3 selected from vinylaromatic compounds, n-butyl methacrylate and also alkyl esters of unsaturated carboxylic acids or dialkyl esters of unsaturated dicarboxylic acids, esters A4 selected from alkyl esters of unsaturated carboxylic acids of dialkyl esters of unsaturated dicarboxylic acids, and other free-radically polymerizable monomers A5, and subsequent addition of a second monomer mixture B and further polymerization in the second stage, the mixture B comprising olefinically unsaturated monomers B1 corresponding to A1, esters B2 corresponding to A4, and monomers B3 corresponding to A5, and subsequently adding compounds C having hydrazine or hydrazide groups.

  水性自交联共聚物分散体 ABC 可通过第一阶段自由基引发的单体混合物 A 的共聚合获得，该单体混合物包括具有羰基的烯烃不饱和单体 A1、不饱和羧酸或不饱和二羧酸的单酯 A2、选自乙烯基芳香族化合物、甲基丙烯酸正丁酯以及不饱和羧酸的烷基酯或不饱和二羧酸的二烷基酯的单体 A3、选自不饱和羧酸的烷基酯或不饱和二羧酸的二烷基酯的酯 A4 和其他可自由基聚合的单体 A5、选自不饱和羧酸的烷基酯或不饱和二羧酸的二烷基酯的酯 A4，以及其他可自由基聚合的单体 A5，然后加入第二单体混合物 B 并在第二阶段进一步聚合，混合物 B 包括对应于 A1 的烯烃不饱和单体 B1、对应于 A4 的酯 B2 和对应于 A5 的单体 B3，然后加入具有肼或肼基团的化合物 C。
• IN-MOLD-COATED AUTOMOTIVE INTERIOR AND OTHER PRODUCTS, AND METHODS FOR MANUFACTURING SAME
  申请人：Shane Kyle

  公开号：US20080236448A1

  公开（公告）日：2008-10-02

  Described are in-mold coated products such as vehicular components, in-mold coating methods, and in-mold coating compositions, involving the use of aqueous acrylic copolymer dispersions, desirably self-crosslinking.
• In-Mold-Coated Automotive Interior and Other Products, and Methods for Manufacturing Same
  申请人：Shane Kyle

  公开号：US20150197042A1

  公开（公告）日：2015-07-16

  Described are in-mold coated products such as vehicular components, in-mold coating methods, and in-mold coating compositions, involving the use of aqueous acrylic copolymer dispersions, desirably self-crosslinking.