(3S,10bR)-3-methyl-3,10b-dihydro-[1,3]oxazolo[3,2-c][1,3]benzoxazine-2,5-dione | 129893-51-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,10bR)-3-methyl-3,10b-dihydro-[1,3]oxazolo[3,2-c][1,3]benzoxazine-2,5-dione
• CAS: 129893-51-2
• 化学式: C₁₁H₉NO₄
• 分子量: 219.197
• InChiKey: BQIJFIZTVAUBKF-IMTBSYHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S,10bR)-3-methyl-3,10b-dihydro-[1,3]oxazolo[3,2-c][1,3]benzoxazine-2,5-dione 生成 (3R,9bR)-3-Allyl-3-methyl-9bH-1,5-dioxa-3a-aza-cyclopenta[a]naphthalene-2,4-dione
  参考文献：
  名称：

  ZYDOWSKY, THOMAS M.;DE, LARA EDWIN;SPANTON, STEPHEN G., J. ORG. CHEM., 55,(1990) N0, C. 5437-5439

  摘要：

  DOI：
• 作为产物：
  描述：

  三光气 、 salicylalanine 在 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 (3S,10bR)-3-methyl-3,10b-dihydro-[1,3]oxazolo[3,2-c][1,3]benzoxazine-2,5-dione
  参考文献：
  名称：

  The stereocontrolled synthesis of orthogonally protected (R)-α-methyltryptophan

  摘要：

  An expedient and highly stereocontrolled route to (R)-alpha-methyltryptophan and its orthogonally protected analogs has been developed via a four-step conversion from L-alanine in good overall yields. The stereochemistry of the products is confirmed by X-ray diffraction analysis, NMR spectroscopy and optical rotations. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02302-8

文献信息

• ZYDOWSKY, THOMAS M.;DE, LARA EDWIN;SPANTON, STEPHEN G., J. ORG. CHEM., 55,(1990) N0, C. 5437-5439
  作者：ZYDOWSKY, THOMAS M.、DE, LARA EDWIN、SPANTON, STEPHEN G.

  DOI：——

  日期：——
• The stereocontrolled synthesis of orthogonally protected (R)-α-methyltryptophan
  作者：Murray Goodman、Jinfang Zhang、Peter Gantzel、Ettore Benedetti

  DOI：10.1016/s0040-4039(98)02302-8

  日期：1998.12

  An expedient and highly stereocontrolled route to (R)-alpha-methyltryptophan and its orthogonally protected analogs has been developed via a four-step conversion from L-alanine in good overall yields. The stereochemistry of the products is confirmed by X-ray diffraction analysis, NMR spectroscopy and optical rotations. (C) 1998 Elsevier Science Ltd. All rights reserved.